Drop Soup Gastroesophageal Reflux And Stomach Through The Clinical Efficacy Of Disease Treatment

Objective:To observe clinical effect of Hewei Tongjiang soup treatment of GERD, and to evaluate long-term efficacy (recurrence rate) and the security.Methods:By endoscopy,24hours pH monitoring, Gerd Q questionnaire and liver Qi attacking the stomach syndrome symptoms of GERD classific-ation quantization table for patient diagnosis, take a simple random method, according to the order of treatment, the patient who met the inclusion criteria be divided into treatment group and the comparison group. Chinese medicine treatment group was given Hewei Tongjiang soup treatment, while the western medicine group was given Rabeprazole Sodium Enteric-coated Tablets treatment. The observation period is four weeks and the treatment last for eight weeks. Take the questionnaire, before the treatment, after treatment for one week, after the treatment two weeks, after treatment three weeks, after treatment for four weeks, four weeks after discontinuation, to understand the changes in patients with the symptom score and endoscopy, to evaluate the therapeutic effect and the security. Symptoms and recurrence was observed after stopping treatment.Results:Clinical and therapeutic effect of syndrome:From first week to third week, two groups of TCM syndrome score showed no significant difference (P>0.05); At fourth week, treatment with traditional Chinese medicine treatment group TCM syndrome score (3.35±3.08) is lower than that of the control group (4.95±4.41). The difference was statistically significant (P=0.026, P<0.05). After two weeks treatment, the effective rates of the two groups had no significant difference, P>0.05; Four weeks after the treatment, Chinese medicine treatment group TCM syndromes efficiency (94.1%) was higher than that of the control group of western medicine (81.8%). The difference was statistically significant (P=0.045,P<0.05) Four weeks after the treatment, Chinese medicine treatment group Gerd Q score (1.38±1.46) was lower than western medicine control group (2.55±3.80), the difference was statistically significant (P=0.000,P<0.05).This shows that in the short term the onset time of Chinese medicine treatment group and Western medicine control group is similar. With the extension of treatment time, treatment of traditional Chinese medicine began to show advantages. Chinese medicine treatment group curative effect is more lasting.Effect of individual symptoms:After four weeks of treatment, compared two groups of treatment of acid reflux symptoms, there was no significant difference (P>0.05); Treatment efficiency of two groups of treatment of acid reflux symptoms were80.0%/78.9%. There was no significant difference (P>0.05). After four weeks of treatment, compared two groups of treatment of heartburn symptoms, there was no significant difference (P>0.05); Treatment efficiency of two groups of treatment of heartburn symptoms were92.0%/94.1%. There was no significant difference (P>0.05). After four weeks of treatment, compared two groups of treatment of retrosternal pain symptoms, there was no significant difference (P>0.05); Treatment efficiency of two groups of treatment of retrosternal pain symptoms were82.4%/81.8%. There was no significant difference (P>0.05). This shows that the two groups have similar effect in the improvement of acid reflux, heartburn, chest pain symptoms. Therapeutic effect of endoscopic:After four weeks of treatment, traditional Chinese medicine treatment group curative effect of endoscopic efficiency (44.4%) was higher than that of the control group of Western Medicine (40%). The difference was statistically significant (P=0.023,P<0.05). The curing esophagitis curative effect of traditional Chinese medicine group is better than western medicine group.Effect of continuous stability:Four weeks after the therapy, Chinese medicine treatment group the recurrence rate (2.9%) is lower than the control group of Western Medicine (22.7%). The difference was statistically significant (P=0.03, P<0.05). Chinese medicine treatment group was more stable and not easy to relapse compared with Western medicine. Adverse events:During the treatment of Chinese medicine treatment group one patients appeared bloated aggravating, without special treatment, and then the symptoms disappeared. Western medicine control group had no adverse events. Two groups for the incidence of adverse events compared, had no significant difference (P=1.000, P<0.05), indicating that two groups are similar in safety.Conclusion:Hewei Tongjiang soup in the treatment of gastroesophageal reflux disease of liver Qi attacking the stomach symptom has a good clinical effect. It can not only improve the clinical symptoms, but also has low recurrence rate and good safety.