The Relationship Between Serum YKL-40and Risk Factor In Patients With Metabolic Syndrome

Objective To study the relationship between serum YKL-40and riskfactor in patients with Metabolic Syndrome．Methods Serum YKL-40were measured by enzyme-linked immunosorbentassay in40cases with metabolic syndrome、73cases without metabolicsyndrome and23health subjects.In all subjects,no risk factor group(n=23),one risk factor group（n=43）,two risk factor group（n=30）,three riskfactor group（n=28）,four risk factor group（n=12）.Results The levels of serum YKL-40（ng/ml）were significantly higherin patients with MS than that in patients without MS or the normal controlsubjects（94.51±35.80>51.77±14.41>31.30±14.61,P<0.01），Serum YKL-40level was positively correlated with the number of risk factors of MS,serum YKL-40increases15.020ng／ml for Each additional risk factor.Multiple factors regression analysis showed that YKL-40were positivelycorrelated with blood glucose and body mass index.The seriousness of thesingle risk factor analysis showed that fasting plasma glucose,BMI,TG,HDL-C,smoking,systolic blood pressure,uric acid had greater influenceon metabolic syndrome.Conclusions The levels of serum YKL-40were significantly elevatedin MS patients，the more risk factors，the higher level of YKL-40.