The Analysis Of Liver And Kidney Insufficiency Postmenopausal Osteoporotic Fractures

ObjectiveThe aim of this study was to analyze the risk factors for postmenopausal osteoporotic fractures with deficiency of liver and kidney and to detect the relationship between biochemical markers of bone metabolism and postmenopausal osteoporotic fractures.MethodBetween June2012and March2014,133postmenopausal women who came from The First Affiliated Hospital of Guangzhou University of TCM were included in our study. According to TCM diagnostic criteria and Western diagnostic criteria, and osteoporosis inclusion and exclusion criteria,90cases were qualified selected and divided to none osteoporosis and none fracture group(blank control group), osteoporosis and none fracture group(control group), osteoporosis and fracture group(experimental group), each group is30cases, experimental group and control group were collectively referred to as conditional control group.Lumbar spine BMD was measured by dual-energy X-ray absorptiometry scans, fasting blood was qualified drawn and send to the laboratory to detect biochemical markers of bone metabolism, such as serum P1NP, β-CTx,25-(OH) VitD and Ca. The results were considered significant at P<0.05. Student’s test (two tailed, independent) was used to determine the significance of study parameters on a continuous scale among groups.The logistic regression analysis was used to screen the risk factors. The software package used for statistical analysis (SPSS)18.0was used to analyse the data. All data were described as mean±standard deviation (SD).Results1.Age, serum P1NP and serum β-CTx levels were higher in postmenopausal osteoporotic patients compared with non-osteoporotic postmenopausal women. There was no significant among height, BMI, serum25-(OH)VitD and Serum Ca. Age, Serum P1NP,β-CTX levels were higher in postmenopausal osteoporotic patients with Spinal fractures compared with the control group, but Serum25-(OH) VitD was lower the control group. there was not statistically significant among age, weight, height, BMI, BMD.2. There was positive correlation of Postmenopausal Osteoporosis with age and Serum β-CTx, and no correlation with weight, height, BMI, P1NP,25-(OH) VitD and Ca. There was negative correlation of Postmenopausal Osteoporosis Fractures with Serum P1NP, and no correlation with age, weight, height, BMI, BMD,β-CTx and Ca.ConclusionsWith the growing age and elevated serum β-CTx level, the risk of Postmenopausal Osteoporosis might increase. Serum decreased P1NP, serum increased β-CTx and25-(OH) VitD in patients with postmenopausal osteoporosis might predict the increased risk of spinal fractures. Serum P1NP and25-(OH)VitD were the risk factors of predicting postmenopausal osteoporotic fractures.