| Objective: To explore the efficacy and safety of probiotics and probiotic products in postmenopausal women(PMW)with osteoporosis and low bone mass by using systematic reviews and Meta-analysis methods,the results provide evidences and references for clinical treatment.Methods: The studies on the treatment of PMOP with Probiotics have been searched in PubMed,Cochrane Library and so on.The pre-set inclusion and exclusion criteria are oral probiotics or probiotic products as a single or complementary treatment for low bone mass in postmenopausal women.Bone density,bone metabolism indicators and adverse events were showed as research indicators.Reviewers independently evaluated the abstract,full text and extracted data.The fixed-effects model was used to analyze the data.The data was showed as SMD,RR and 95%CI.According to the duration of probiotics intake(≤6 months and >6 months),subgroup analysis was performed.The risk bias and quality of evidence were evaluated.Results: 4 studies were enrolled,including 312 PMW participants.Probiotics improved lumbar bone mineral density(SMD 0.16,95%CI:-0.06～0.38,p=0.161).Subgroup analysis showed the lumbar spine bone density may improve(SMD-0.01,95%CI:-0.34～0.31,p=0.938)when the duration of probiotics was no more than 6months.And the lumbar spine bone density can significantly improve(SMD 0.31,95%CI: 0.00～0.61,p=0.047)when the duration was more than 6 months.Probiotics may improve total hip bone mineral density(SMD 0.15,95% CI:-0.2～0.49,p=0.398).Adverse events were not significantly different(RR 0.95,95%CI: 0.78～1.16,p=0.625).The included studies have a little of risk of biases,but the quality of the evidence was acceptable.Conclusion:Probiotics may adjust BMD and improve bone loss in PMW and are relatively safe.The long-term intake of probiotics(>6 mo)may be more beneficial to lumbar BMD.The existing evidence does not support the widespread use of probiotics in PMOP,large samples and high-quality studies are urgently needed. |
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