An Experimental Research On Liangxuezhiyang Mixture’s Antiallergic And Anti-inflammatory Function And The Clinical Observation For Its Treatment Upon Chronic Eczema

Objectives: This thesis investigates liangxuezhiyang mixture’s antiallergic andthe anti-inflammatory function through animals experiment with an aim to find itspharmacodynamic mechanism and function. At the same time, its clinical effects onthe treatment of chronic eczema are examined through observation, which willprovide theoretical references for Traditional Chinese Medicine in clinical treatment.Methods:1.Experimental Procedure:1.1Observing the tumidness of the mice’s auricle via the Ⅳallergic reactionwith the dinitrofluorobenzene (DNFB) in mice.1.2Using the histamine to make the guinea pigs pruritus locally to find thevolume of the phosphoric acid histamine needed when the guinea pigs turned aroundto lick the infected part;2.Clinical Research:86Chronic eczema patients are selected as theexperimental cases in terms of the given standard and divided them into treatmentgroup and control group randomly. Each group has43patients and is fed withliangxuezhiyang mixture and Loratadine Tablets respectively. Two weeks are set asone course of treatment. Two courses are continually observed in which theperformance and integral of pruritus degree, lesionpatters and lesion area before and after the treatment are recorded. Meanwhile, safetyassessment of the test medicine is made during the treatment course.Results:1.The experimental results reveal:1.1The ear weight D-value of Liangxuezhiyang mixture group is(0.0156±0.0069)g; the positive control group is(0.0187±0.0074)g;the model group is(0.0259±0.0047)g. When P＜0.05, it indicates that there are diffences on the three groups. When P＞0.05, it indicates that there are no difference in Liangxuezhiyang mixturegroup and the positive control group.1.2The pruritus threshold of histamine phosphorus in the guinea pigs of theLiangxuezhiyang mixture group is(98.0000±32.9309)mg, the positive control groupis (91.5000±29.6320)mg;the model group is(52.0000±22.5093)mg. When P＜0.05, it indicates that there are diffences on the three groups. When P＞0.05, itindicates that there are no difference in Liangxuezhiyang mixture group and thepositive control group.2.The Clinical Research results reveal:2.178Chronic eczema patients are selected（Excluding8patients）,the effectiverate of the treatment group is80.00％and the control group is76.32%. When P＜0.05,it indicates that both groups have the similar fuction on chronic eczema.2.2Afteher1month,the recurernce rate of the treatment group is10%and thecontrol group is66.67%. When P＜0.05, it indicates that the the recurernce rate ofthe treatment group is better.2.3The adverse event:there is no one adverse event in both groups.Conclusion1.It indicates that liangxuezhiyang mixture with a good anti-allergic andAnti-inflammatory function through the animal experiments.2. It indicates that liangxuezhiyang mixture with an antipruritic effects throughthe animal experiments.3.The clinical observation implies that total effective rate of the treatment groupof liangxuezhiyang mixture is similar to that of the control group of Loratadinetablets. And liangxuezhiyang mixture has a good curative effect and safety for curingthe eczema.