The Study Of Diagnosis Value For Breast Cancers With Different Sizes By Ultrasonic Elastography Technology And Mammography

BackgroundBreast cancer, one of the malignant tumors with high rate of incidence forfemales worldwide, ranks fourth death rate for female cancers; and the incidence rateis on the rise in recent years. Although it is comparatively easy to find out breastcancer in its early phase, there are no overt symptoms for some of the breast cancerpatients in its early phase with the lump not touched or identified, as a result thepathogenetic condition of patients has been metastasized. Therefore, discovery anddiagnosis in its early phase is the key to improve the curative effect for breastcancer.Breast cancer in its early phase presents non-infiltrating cancer, and one of itsfairly common types is ductal carcinoma in situ (DCIS), which refers to cancer cells,being localized in the basement lamina of mammary duct, can not break through thebasilar membrane. Because of low metastasis and eusemia of DCIS, early diagnosisand discovery is of great clinical significance for treatment and prognosis. UltrasonicElastography (UE), an ultrasonic diagnosis technique widely used in recent years, canbe used to distinguish the benign or malignant nidus through the determination for theelasticity features of tissues. Molybdenum target X-Rays photography is an acknowledged, reliable and effective diagnosis technique of iconography to diagnosethe early-phase breast cancer. However, the nidus size of breast cancer whether or notinfluences the diagnostic value of the two techniques mentioned above is rarelyreported. Molybdenum target X-Rays photography has been always the preferreddiagnosis technique of iconography for screening DCIS. Because of its sensitivity tocalcification, it is reported that about80percent DCIS can be diagnosed anddiscovered with only molybdenum target X-Rays; and the research on the diagnosticvalue of elasticity imaging is rare, too.This study’s main purpose is, with pathology as golden standard, to probe intothe diagnostic value of ultrasonic elasticity imaging technique and molybdenumtarget X-Rays on different sizes of breast cancer nidus; at the same time, inaccordance with the elasticity imaging and molybdenum target X-Rays sonogramfeatures of DCIS, the diagnostic values of both techniques will be analyzed.Objects and Methods1.To select115cases of breast cancer patients screened with ultrasonic elasticityimaging and molybdenum target X-Rays diagnosis preoperatively and confirmedpostoperatively by pathology in our hospital during2011and2013, with total137niduses of female patients between20and70years old, the mean age of who is(45±12).2.Each patient goes through the preoperative diagnosis of ultrasonic elasticityimaging and molybdenum target X-Rays respectively. The routine ultrasonographywill be performed first, and the2-dimensional sonogram and blood stream featureswill be recorded. On this base, elasticity score will be checked at the end, accordingto different colors shown in nidus, and five-score method will be used in evaluation;score1～2is benign,≥3malignant, and the respective numbers of benign andmalignant nidus diagnosed with elasticity imaging technique will be recorded.Molybdenum target X-Rays diagnosis will record the image features in accordancewith the diagnostic classification of mammary iconography and report data system inNorth America; the respective numbers of benign and malignant nidus casesconfirmed with molybdenum target X-Rays will be recorded.3. According to the long axis in ultrasonogram,137niduses are divided into three groups: S1group, the diameter≤10mm; S2group of diameter between11～20mm; and S3group of diameter>20mm. The total numbers of cases for each group,the respective numbers of benign and malignant nidus diagnosed by elasticityimaging and molybdenum target X-Rays respectively in each group all will berecorded; then the sensitivity and specificity of breast cancer diagnosis will becalculated and analyzed comparatively.4.To comparatively analysis the elasticity imaging and molybdenum targetX-Rays ultrasonogram features of137cases of DCIS niduses, and the diagnosticvalue of two techniques on DCIS niduses.Results1.The sensitivity and specificity of breast cancer diagnosis by elasticity imagingin group S1are88.9%、76.2%;88.1%、78.5%in group S2;71.2%、72%in groupS3.The sensitivity and specificity of breast cancer diagnosis by molybdenum targetX-Rays in group S1are47.2%、78.3%;74.1%、86%in group S2;72.3%、68%in groupS3.The ultrasonogram elasticity imaging’s diagnosis sensitivity on the malignantniduses in both S1and S2groups is higher than that on S3group(P<0.05), the twotechniques show no obvert difference on the diagnosis specificity of the threegroups(P＞0.05). The elasticity imaging’s diagnosis sensitivity of intergroup showsno obvert difference for S1, S2and S3groups(P＞0.05).2.The features of Ductal carcinoma of the breast by teasting in the way ofelastography and X-ray mammographyConclusions1.The diagnostic specificity of molybdenum target has nothing to do with thelump size, but the diagnostic specificity of elasticity imaging is relatively high insmall nidus of breast cancer. Combination of two techniques can improve theaccuracy of diagnosis and reduce diagnostic errors.2.Elasticity imaging has specific diagnostic value on DCIS; the diagnosticaccuracy can be improved by elasticity imaging combined with molybdenum targetmethod.