The Study On The Relationship Between Tumor Laboratory Indicators Of Colorectal Cancer In Traditional Chinese Medicine

Purpose:In order to provide an objective basis for the classification of the TCM syndrome types and the the treatment of integrated traditional Chinese and Western medicine in patients with colorectal cancer, we classify the patients into different TCM syndrome types, detect the clinical pathological characteristics, the expression of Ki-67, VEGF, TS, ERCC1, K-Ras and so on in the tumor tissue and analyse the internal relationship between TCM syndromes and clinical objective data.Method:We choose a total of96patients with primary colorectal cancer treatment in traditional Chinese medicine of Jiangsu Province and Jiangsu Province Tumor Hospital from April2013to December2013. We classify them into different TCM syndrome types.We collected the clinical data, including gender, age, postoperative pathological characteristics, the expression of Ki67, P-gP, VEGF, TS, ERCC1, K-Ras in the tumor tissue.Then establish a database using the SPSS17.0software to analysis the relationship between TCM syndromes and objective data, count data was checked by chi-square test, measurement data was checked by analysis of variance, P<0.05is regarded as statistical difference.Result:The incidence of colorectal cancer in male to female ratio is1.5:1and the age of41-50is most. Spleen deficiency and qi stagnation syndrome, endoretention of damp heat syndrome and stasis poison resistance syndrome is the most common type of syndrome of colorectal cancer(P<0.01).Spleen deficiency and qi stagnation syndrome has significant correlation with high incidence of moderately differentiated tubular adenocarcinoma, high levels of CEA, high level of CA199, the high level of Ki-67, high expression of ERCC1and K-Ras high mutation rate(P<0.01). The endoretention of damp heat syndrome has significant correlation with high incidence of moderately differentiated tubular adenocarcinoma, high levels of CEA, high level of CA125,high positive rate of P-gP, the high expression of VEGF and TS(P<0.01). The stasis poison resistance syndrome has significant correlation with high incidence of low differentiated tubular adenocarcinoma, high levels of CA125, high positive rate of P-gP and VEGF(P<0.01).The spleen kidney Yang deficiency syndrome has significant correlation and with high incidence of moderately differentiated tubular adenocarcinoma,high levels of CA199, high expression of VEGF, high expression of ERCC1and high mutation rates of K-Ras(P<0.01). The liver and kidney Yin deficiency syndrome has a significant correlation with high positive rate of P-gP, the high level of Ki-67and high expression of ERCC1(P<0.01). Qi and blood deficiency syndrome has a significant correlation and with high levels of CA199, high expression of TS and high mutation rate of K-Ras(P<0.01).Conclusion:The TCM syndrome types of colorectal cancer had little relationship with age and sex. Spleen deficiency and Qi Stagnation with high degree of malignancy, poor effect of platinum based chemotherapy. Endoretention of damp heat in a high degree of malignancy, poor effect of fluorine on chemotherapy, bevacizumab, Sola Feeney targeted therapy. Blood stasis and toxin resistance permits a high degree of malignancy, survival time is short, may be on bevacizumab, Sola Feeney targeted therapy. Yang deficiency of spleen and kidney on the effect of platinum based chemotherapy is poor, poor cetuximab treatment, may to bevacizumab, Sola Feeney targeted therapy. Liver kidney yin deficiency syndrome is not sensitive to platinum based chemotherapy, prone to drug resistance. Deficiency of Qi and blood of two fluorine based chemotherapy and cetuximab treatment effect is poor.