Effection Of Type2Diabetes Mellitus On Epicardial Adipose Volume Of Patients With Coronary Heart Disease

Background In resent years, the morbidity and mortality of coronary heart disease (CHD) showed an increasing trend that became one of the serious diseases threats to human quality of life and expected life.Diabetes mellitus (DM) also turned into one of serious threats to human health. Patients with type2diabetes mellitus (T2DM) were more than90%of the total patients with diabetes mellitus. It was an independent risk factor for cardiovascular diseases. Both coronary heart disease and diabetes mellitus had multiple and common risk factors. Visceral obesity is one of the factors. Epicardial fat tissue (EAT) which is visceral fat deposits around the heart, especially surrounding the coronary arteries.It plays an important role in the occurrence and development of coronary atherosclerosis.Objectives The study will compare with epicardial adipose volume of coronary heart disease in patients with type2diabetic CHD and non diabetic CHD, to discuss effection of type2diabetes mellitus on epicardial adipose volume and degree of coronary artery lesions of patients with coronary heart disease.Subjects and Methods A total of78patients suspected for CHD who confirmed by coronary artery CT angiography(CTA) and diagnosided.Then patients in hospital was proper diagnosised by coronary angiography (CAG) in a week.The patients were divided into two groups:38CHD patients with type2diabetes mellitus (mean age60.2±4.5years),and40CHD patients without type2diabetes mellitus(mean age61.3±4.7years).78patients were examined the levels of fasting plasma glucose(FBG), triglycerides (TG), total cholesterol(TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) after an overnight fast. All patients were scaned to measure by coronary artery CTA.The volume of EAT was measured with a dedicated software program-Volume. Degree of coronary artery lesions was evaluated through counts of coronary vessel and Gensini scores. The clinical features and the data from selective coronary angiographies were compared between type2diaberic and non diabetic CHD patients. SPSS16.0was used to perform the statistical analysis. The measurement data was compared using t test and count data were compared using the chi-square test between the two independent samples. The clinical features and the data from selective coronary artery CTA was compared between type2diabetic and non diabetic CHD patients.The difference of EAT volume was analyzed using t test in the present study. Statistical significance was set at P<0.05.Results (1) EAT volume of type2diabetic CHD patients was103±9.86cm3; EAT volume of non diabetic CHD patients was91.3±10.96cm3. The difference between the two groups was very significant.(2) The group of type2diabetic CHD patients had greater BMI, FBG, TG, TC, LDL-C, coronary vessel and Gensini scores and lower HDL-C than non diabetic CHD patients.Conclusions (1) Patients with type2diabetic CHD had more EAT volume and severe degree of coronary artery lesions than non diabetic CHD patients.(2) EAT volume is positive correlation with BMI, FBG, TG, TC, LDL-C.But it is negative correlation with HDL-C.