| Objective: To evaluate the effect of comprehensive intervention on patients with dyslipidemia in Kazakh or Uygur, put the forward reasonable foundation for the effect of comprehensive in rural areas of the remote poverty of minorities.Methods: 1. With cluster random sampling, the subjects were selected the permanent residents who is Kazakh or Uygur and older than 18 years in Xinjiang(Xinyuan,Yili;Jiashi,Kashi) as baseline survey of the object.2. Using the way of home visit to collect information related to the questionnaire, physical examination and blood specimen collection, and serum total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), fasting plasma glucose(FPG) were detected with OLYMPUS 2007 automatic biochemical analyzer. The high blood pressure and dyslipidemia were selected by the diagnostic criteria for metabolic syndrome made by International Diabetes Federation in 2005. According to dyslipidemia or not, the cases were split into 2 groups. The follow-up survey were carried out from 2011 to 2012 regularly, it was include strengthened education, distributed drugs freely, collected follow-up table information, physical examination and collection of blood, blood biochemical tests completed. Outcome survey was used the same way to visit and had the same content.3. All statistical analyses were performed using the SPSS17.0 statistical software. Normal distribution data was described as(x±s),the measurement data between the two groups were compared with t test; repeated measurement data was used to be analyzed by the ANOVA for repeated measurement data; count data was used to compare the rate of Pearson χ2 test, and trend Pearson χ2 test.Results: 1. In baseline survey, we selected 784 cases with hyperlipidemia, three years later there were 460 cases behind, the follow-up rate was 88.0%; there were 94 people lost.2. Compared with baseline lipid levels,the mean percent change in TC,LDL-C and HDL-C 2.80%、12.12%23.00%had a significantly better with control rate(2.80%、12.12%、23.00%)compared with control group.3. Compared to baseline, patients in the intervention group of TC, LDL-C levels were reduced(4.06±0.94)mmol/L、(2.03±0.61)mmol/L(P<0.05), HDL-C levels were increased(1.23±0.46)mmol/L(P <0.05). The lipid control rate of intervention group significantly higher than control group(38.70% vs 3.48%, χ2 =62.407,P<0.001).4. After the intervention activities, between the intervention group and control group the average levels of dyslipidemia knowledge are respectively26.2%、5.5%, attitude are respectively 35.1%、7.5% and behaviors are respectively 12.9%、3.7%.5. Two group of dyslipidemia knowledge scores are respectively(3.32±2.19)、(1.39±1.18), attitude scores are respectively(2.07±1.27)、(0.82±0.92), behavior scores are respectively(1.11±1.10)、(0.70±0.96), thetotal average scores are respectively(6.50±3.30)、(2.91±2.31)(P<0.01).Conclusion The levels of dyslipidemia knowledge, attitude and behaviors are very low in the rural dyslipidemia patients of Uygur and Kazakhs in Xinjiang.Sustained and effective health education can increase the levels of the dyslipidemia knowledge, attitude and behaviors.Conclusion: By carrying out the comprehensive intervention of health education and drug treatment over 3 years, we completed the effects of combination intervention of small dose of drugs and health education are well, and the program could be used in rural areas of minorities. The comprehensive intervention is effective and practicable, which can be able to conduct to control and reduce their lipid levels, increase the control rate and the level of KAB, and to improve health and life-quality finally. |
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