| Objective: 1. To investigate on the clinical chronic atrophic gastritis TCM Distribution Features. 2. To study the efficacy of the Xiaowei decoction on the spleen and stomach type of CAG, for further clinical studies provide a basis by explore the role of principle in the treatment of CAG.Methods: 1.To retrospectively survey by Anhui University of Traditional Chinese Medicine First Affiliated Hospital admissions department cadres stomach of the last five years and diagnosed as chronic atrophic gastritis of the patients, via symptom characteristics of all symptoms, tongue and pulse analysis of its type, the characteristics of TCM syndrome distribution of clinical CAG. 2. To collect from January to December 2015 CAG cases of 50 outpatients and inpatients with the spleen and stomach by Anhui University of Traditional Chinese Medicine First Affiliated Hospital admissions department cadre stomach.By Randomized single-blind of the random number table select 60 random numbers successive.With the order of treatment of patients to the hospital in accordance, each patient corresponds to an random number, an odd included in treatment group, 30 cases Xiaowei decoction party group;even included in the control group, that is weifuchun group 30 cases.The treatment group by Xiaowei decoction, one day by 2 times for morning and evening taking half an hour after meals.The control group was treated with weifuchun four pills each time by three times a day.By the two groups during treatment the other of gastropathy treatment drugs are disabled.Continued treatment 12 weeks as a course.To observed the improvement situation before and after the treatment,such as,the clinical symptoms,pathological atrophy,intestinal metaplasia,epithelial dysplasis and pepsinogens.Results: 1. Through the retrospective studies have shown that in patients with 480 cases of chronic atrophic gastritis.The syndrome distribution is:Spleen-stomach deficiency type>Stomach qi stagnation>Liver-stomach heat type>Spleen-stomach damp-heat type>Stomach-yin deficiency type>Stagnation in blood of gastric vascular type. In this disease,Spleen-stomach deficiency type is the most common type of syndrome. Stagnation in blood of gastric vascular type is rare. 2. As the following results for Xiaowei decoction of CAG spleen and stomach type of clinical observational studies: 2.1 Clinical observation discovered that the treatment group Xiaowei decoction treatment of chronic atrophic gastritis spleen and stomach type of total effective rate is 90%.While the control group the total effective rateis 63.33%.By statistical analysis of the differences between two groups with statistical significance(P<0.05).That is direction the treatment group is superior than the control group. 2.2 Compared to the two patients are symptom total score.The two groups of patients before treatment the total score of symptoms is not statistically significant(P>0.05),which is comparable.Before and after treatment comparison of symptom total score are statistically significant(P<0.05).Score before and after treatment on two groups of cases were analyzed, and the statistical comparison in the group have difference(P<0.05).And in some aspects of symptom score after the treatment of the two group,such as fullness of abdomen,pain of stomach,loose stool,weakness,belch, acid regurgitation,eating less are statistically significant compare to the before treatment(P<0.05).After the treatment of the fullness of abdomen, pain of stomach, belching through comparison between the two group, also have statistical significance(P<0.05).Thus it show that the treatment group of the fullness of abdomen,pain of stomach,belching curative effect is significantly higher than the control group. Other symptoms are there is no statistically significant difference by statistical analysis 2.3 The efficacy of the two groups of patients in aspects of pathology:After the treatment in patients treated with atrophy, intestinal metaplasia,epithelial dysplasis of the total efficiency of are 86.96%,77.27%,33.33%.They are higher than the after treatment in the control group,which are 54.54%,55.56%,20.00%.By statistical analysis, the two group compared to atrophy and intestinal metaplasia are statistically significant(P<0.05);epithelial dysplasis are not statistically significant(P<0.05).But the total efficiency of the treatment group than the control group. Therefore indicating Xiaowei decoction treat CAG of atrophy and intestinal metaplasia by remission the progress. 2.4 Comparison the pepsinogen detection: After the treatment, the treatment group of PGⅠand PGR are increased, PGⅡis lower,which the difference are statistically significant(P<0.05).After the treatment,PG Ⅰ and PGR of the control group are increased, which the difference are statistically significant(P<0.05).Two groups of patients are compares after the treatment.The treatment group of PGⅠand PGR were higher than the control group, while PGⅡlower than the control group, the difference are statistically significant(P<0.05).There are show that Xiaowei decoction has protect the gastric mucosa in the treatment of CAG better than the control group.Conclusion: 1. The past five years in patients with chronic atrophic gastritis, Anhui University of Traditional Chinese Medicine First Affiliated Hospital Division of cadres stomach with the spleen and stomach is the most common type. 2. To the observation of clinical efficacy of the treatment of CAG spleen and stomach type by Xiaowei decoction.It illustrated that Xiaowei decoction is significantly improved the clinical symptoms of chronic atrophic gastritis patients with spleen and stomach.And can effectively alleviate the pathological atrophy, intestinal metaplasia manifestation. The pepsinogen improvement also have certain curative effect.So it shows Xiaowei decoction is safety and effective prescription treatment of chronic atrophic gastritis with spleen and stomach. |
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