Clinical Effectof Qingre Huayu Prescription In Treating Acute Ischemic Stroke And The Influence Of NSE

Objective:To observe the clinical efficacy and safety of Qingre Hua yu Prescription in the treatment of acuteischemic stroke and the influ ence of Neuron Specific Enolase(NSE),which providing scientific ba ses for clinic application and therapeuticmechanism.Methods:80 cases of acuteischemic stroke patients were randomly div idedinto treatment group and control group.Then controlgroup was giv enregular therapy,while treament group was given regular therapyand Qingre Huayu Prescription.After the treatment of4 weeks,we obser-ve d the changes of mRS(Modified Rankin Scale)and BI(Bathel-Index).At the same time,the concentrations of blood NSE were measured in patients before and after therapy by means of ELISA method.Results:(1)mRS and BI: Modified Rankin Scale and Bathel-Index b oth revealed that the scores significantly increased after treatment.There was significantly difference(P<0.05)between pretherapy and posttreatment,and the treatment group was superior to the control group(P<0.05).(2)NSE:Theconcentrations of blood NSE significantly decreas-ed in b oth groups(P<0.05),and the the treatment group was superiorto thatin the control group(P<0.05).(3)Safety evaluation:There was no significantly difference in the Blood RT,Urine RT,Stool RT and function of Liver and Kidney between pretherapy and post-treatment(P>0.05),and no adverse reactions were found,which confirmed that Qingre Huayu Prescription had good safety,and most of population can take this drug safely.Conclusions : This study showed that Qingre Huayu Prescription has curative effect in the treament of acute ischemic stroke with wind-phl egm and blood stasis in collateralsthrough downregulating the express-i on ofNSE.