To Observe The Clinical Effect Of Simotang Oral Liquid Combined With PPI In The Treatment Of Gastroesophageal Reflux Disease

Objective This study adopted randomized control method to observe the clinical curative effect,gastroscope curative effect and the improvement of quality of life in the Simotang oral liquid combined with PPI treatment of liver stomach disharmony of gastroesophageal reflux disease,so as to provide a new choice for clinical treatment for gastroesophageal reflux disease thereby.Methods The paper selected 59 cases were randomly divided into A1 group of 30 cases,and A2 group of 29 cases,A1 group was given by pantoprazole 40 mg oral 2/day,and Simotang oral liquid 20 ml oral2/day for 2 weeks,after 2 weeks,the pantoprazole 40 mg oral1/day,and Simotang oral liquid 10 ml oral 2/day for 2 weeks,A2 group was treated with pantoprazole 40 mg oral 2/day for 2weeks,after 2 weeks,pantoprazole 40 mg oral 1/day for 2 weeks,that is,both groups were treated for 4 weeks.Before treatment,after2 weeks and 4 weeks of treatment,the clinical symptom score,and quality of life score of the two groups were recorded,as to observe the differences of clinical symptoms and the improvement of the quality of life in the different treatment stages;beforetreatment,the two groups of patients underwent gastroscopy,and after 4 weeks of treatment the patients who were diagnosed with reflux esophagitis were given gastroscopy again,so as to observe the difference of gastroscopic effect in the two groups of patients;before treatment and after 4 weeks of treatment,two groups of patients were given blood routine,urine routine,stool routine,liver function,kidney function,electrocardiogram inspection,then recorded the inspection results and occurrence of adverse reactions during the course of treatment,as to investigate the drug safety situation.Results(1)Clinical symptoms integral comparison:the acid reflux,heartburn,chest pain,belching,irritability,anorexia,epigastric noisy,distension symptoms score and total score of A1 group after treatment compared with before treatment were decreased(p<0.05),and the acid reflux,heartburn,belching,epigastric noisy symptom score and total score decreased significantly(p<0.01);the acid reflux,heartburn,chest pain.noisy belching,epigastric symptoms score and total score of A2 group after treatment compared with before treatment were decreased(p<0.05),and the reflux symptoms score and total score decreased significantly(p<0.01);after treatment,the acid reflux,heartburn,belching symptoms score and total score of A1 group were lower than A2 group(p<0.05),and the difference of acid reflux and belching score between the two groups were significantly(p<0.01).(2)Clinical symptoms comparison:after 2weeks and 4 weeks of treatment,A1 group cure rate and total effective rate were both higher than A2 group,but the differences of cure rate and total effective rate after two weeks of treatmenthad no statistical significance(p>0.05);after 4 weeks of treatment,the difference of the cure rate was statistically significant(p<0.05),and there was no significant difference in the total efficiency(p>0.05).(3)Gastroscope curative effect comparison:after 4 weeks of treatment,A1 group cure rate and total effective rate were higher than A2 group,but the difference of cure rate had no statistical significance(p>0.05);and there was a statistically significant difference in the total efficiency(p<0.05).(4)The quality of life scores comparison:compared with before treatment,the quality of life scores of the two groups were decreased significantly after 2 weeks of treatment(p<0.01);compared with after 2 weeks of treatment,the quality of life scores of the two groups were decreased significantly after 4 weeks of treatment(p<0.01);after 2 weeks of treatment,the quality of life score of A1 group was lower than that of A2 group,but the difference was not statistically significant(p>0.05);after 4 weeks of treatment,the quality of life score of A1 group was lower than that of A2 group,and the difference was statistically significant(p<0.05).Conclusion Compared with acid suppression therapy alone,the improvements of acid reflux,heartburn,belching symptoms of Simotang oral liquid combined with PPI in the treatment of liver stomach disharmony of gastroesophageal reflux disease are better,it can make up the pure acid suppression therapy to alleviate patients with anorexia,irritability,lack of distension symptoms;after 4 weeks of treatment,the improvements of cure rate of clinical symptoms and total effective rate of gastroscopy are better,the improvement of quality of life is better too.