| Objective:A retrospective analysis of the correlation between serum alkaline phosphatase levels and coronary heart disease,and the value of its conduct risk stratification of CHD.Methods:314 patients with chest pain and chest tightness were enrolled in this study.General data such as age,sex and blood pressure were collected and data such as liver function,renal function,blood lipid and blood glucose were collected.According to the results of coronary angiography confirmed CHD221 cases,including stable angina pectoris 62 cases,89 cases of unstable angina pectoris and acute myocardial infarction70 cases.In the CHD group,there were 51 cases of elevated ALP and 170 cases of normal ALP.According to the degree of coronary artery stenosis Gensini score recorded,Gensini <40 severe stenosis,151 cases.According to the Rentrop rating of coronary collateral circulation,Rentrop 0-1 grade was coronary artery collateral circulation,112 cases.The incidence of major cardiovascular events in CHD group was recorded for six months.A retrospective analysis of correlation between ALP levels and CHD clinical type,severity of coronary artery disease,coronary collateral circulation and the occurrence of MACCE,ALP and analysis associated with other traditional indicators,explore the correlation between levels of ALP and CHD.Results : 1.ALP concentrations increased in total 59 cases,the detection rate of18.79%.Among them,51 cases were CHD group,the abnormal rate was 23.08%;8cases in non-CHD group,the abnormal rate was 8.6%.The former was significantly higher than the latter,the difference was statistically significant,x2 value of 4.738,P<0.05.ALP elevated in 50 males,the detection rate of 84.7%;9 females,the detection rate of 15.3%.The difference was not statistically significant,P> 0.05.2.Multivariate logistic regression analysis showed that ALP levels were independent factors of CHD(OR1.027,95% CI 1.013-1.040,P <0.05).3.ALP level was significantly higher in the severe stenosis group(101.3 ± 50.6U / L)>non-severe stenosis group(78.0 ± 38.8U / L),the difference was statistically significant(P <0.05).Multivariate logistic regression analysis showed that ALP level was an independent factor in coronary artery stenosis(OR1.013,95% CI 1.103-1.023,P <0.05).4.ALP level was significantly higher in the multivessel disease group(80.80 ± 29.37U/ L)> double vessel disease group(76.53 ± 18.15 U / L)> single vessel disease group(73.95 ± 23.15 U / L),the difference was not statistically significant,P> 0.05.5.There was no significant difference in ALP level between SAP group(78.08 ±50.05 U / L),UAP group(80.08 ± 48.80 U / L)and AMI group(79.80 ± 50.30 U / L).6.Of the CHD group,112(51%)observed impairment of CCC.There was a correlation between ALP levels and CCC impaired grade,with high ALP levels associated with CCC impairment(65% vs 51%,p = 0.03).7.Multivariate logistic regression analysis showed that elevated ALP levels were independent factors of CHD MACOC(OR1.112,95% CI 1.203-1.623,P <0.05).8.ALP levels were positively correlated with coronary stenosis,hypertension,and C-reactive protein,r values were 0.452,0.166,0.387.Conclusions: 1.Serum ALP levels were positively correlated with CHD,which may be an independent risk factor for CHD.2.The level of ALP is also associated with coronary artery stenosis and may be an indicator of the severity of coronary artery disease.3.The level of ALP can be used to assess whether the CCC is damaged.4.Elevation of ALP can be used as one of the risk factors for MACD in CHD.5.ALP levels were positively correlated with C-reactive protein. |
PDF Full Text Request