Correlation Between Serum Non-HDL-C Level And The Condition Of Patients And The Severity Of Coronary Artery Lesion With Coronary Heart Disease

Objectives To investigate the correlation between serum Non-HDL-C level and the condition of patients and the severity of coronary artery lesion with coronary heart diease.Methods During January 2014 to October 2016 in North China Polytechnic University Hospital Department of Cardiology underwent coronary angiography(CAG),533 cases of patients were selected,among which,there are 100 cases of non CHD patients,433 CHD patients;among the 433 case,there are 314 patients with angina pectoris(AP)and 119 patients with acute myocardial infarction(AMI).Base on the lever of Non-HDL-C,it is divided into three groups,Non-HDL-C<3.27mmol/L as the low Non-HDL-C group,3.27mmol/L≤Non-HDL-C<4.16mmol/L for the middle group and Non-HDL-C >4.16mmol/L as the high Non-HDL-C group.According to collecting the basic clinical data for all patients,coronary angiography results,the blood lipid indexes and biochemical indexes such as fasting blood glucose,creatinine,uric acid,and Myocardial enzymology index were collected from fasting venousblood,and the Non-HDL-C values were calculated.The data were statistically processed with SPSS19.0 software package,one-way ANOVA,chi square test or nonparametric test were used to analyze the baseline data between the three groups;Spearman correlation analysis was used to analyze the correlation between Non-HDL-C and Gensini score;Logistic regression was used to analyze the effect of Non-HDL-C level on Gensini score,CHD and CHD subtypes.The diagnostic value of Non-HDL-C level for high Gensini score was evaluated by receiver operating curve.Results 1 A total of 533 subjects were included in the study,with an average age of 59.9±1.3 years,of which 346 were male and 187 were female.The prevalencerates of AP in low,medium and high Non-HDL-C groups were 59.8%,65.0% and 51.7% respectively,and the detection rate increased with the increase of Non-HDL-C level.The prevalence rates of AMI in low,medium and high Non-HDL-C groups were 12.3%,18.3% and 36.8% respectively.2 The Non-HDL-C level was positively correlated with the Gensini score of AMI(rs=0.295,P<0.001).3 Multivariate disordered Logistic regression analysis was performed after correcting the potential confounders affecting the Gensini score,the results showed that the risk of high Gensini score in the middle and high Non-HDL-C group compared with the low Non-HDL-C group was respectively(OR=1.87,95%CI: 1.17~2.99,P=0.009);(OR=2.58,95%CI: 1.61~4.13,P<0.001).4 After correcting the potential confounding factors affecting CHD,two yuan Logistic regression analysis showed that,compared with the low Non-HDL-C group,the risk of CHD in the middle and high NonHDL-C group was respectively(OR=2.02,95%CI: 1.19~3.41,P=0.009)、(OR=3.41,95%CI: 1.90~6.11,P<0.001).5 Multivariate disordered Logistic regression analysis was performed after correcting the potential confounders affecting the CHD subtype,the results showed that,compared with the low Non-HDL-C group,the risk of AP in the middle and high Non-HDL-C group was respectively(OR=1.97,95%CI: 1.12~3.48,P=0.019),(OR=2.68,95%CI: 1.40~5.14,P=0.003);the risk of AMI in the middle and high NonHDL-C group was respectively(OR=3.04,95%CI: 1.43~6.44,P=0.004)、(OR=10.68,95%CI: 4.86~23.47,P<0.001).6 Non-HDL-C predicts the area under the ROC curve of high Gensini score,AUC=0.618,P<0.001.Conclusions 1 The level of Non-HDL-C is independently and positively correlated with the severity of coronary artery disease.2 The level of Non-HDL-C is a risk factor affecting the severity of CHD patients.