Professor Wu Shengyuan’s Exprience And Research In Treating Impediment Disease

Objective:Concluding the medication principles adopted by professor Wu Shengyuan as well as his treatment characteristics in treating rheumatism with the help of modern data mining method and literature research,so as to better inherit the academic achievements of old Traditional Chinese Medicine(TCM)practitioners and provide reference for improving the efficacy of Traditional Chinese Medicine in treating impediment disease.Method:1.A study of Professor Wu Shengyuan’s prescription and medication principles in treating rheumatism based on data mining: applying Traditional Chinese Medicine Inheritance Support System(V2.5)to conduct statistical analysis and data mining on prescriptions and medical cases.2.Search Professor Wu Shengyuan’s journals,papers and publications as well as his academic heirs and students’ published papers and learning sharing to summarize the related literature of him and conclude the regular treatment methods and academic views in treating impediment disease.Results:1.The following results were obtained by using Traditional Chinese Medicine Inheritance Support System(V2.5):1.1According to the drug’s "frequency statistics",the top 10 medicines,from the most frequently used to the less,for treating impediment disease are liquorice,jujube,cassia twig,radices paeoniae alba,coix seed,radix astragali,epimedium,atractylodes macrocephala koidz,radix angelicae tuhuo and asarum;through drug’s “four qi analysis”,it is found that warm medicine are the most frequently used,followed by neutral,cold,chilling and heat drugs.In the "five flavor analysis",sweet,acrid and bitter drugs are used the most often;The "Meridian analysis" indicates that drugs contributing to the spleen,lung,liver stomach and kidney appear the most often.1.2 Through the analysis of "prescription principle","support number" and "confidence level" were set to be 7 times respectively and,followed with a finding of a close correlation of ramulus cinnamomi,radix paeoniae alba,licorice and jujube.1.3 Based on the data analysis of “entropy clustering” and “improved mutual information method”,16 new prescription have been obtained,such as radix paeoniae alba,saposhnikovia divaricata,futokadsura stem,rhizoma anemarrhenae,radix glehniae;ophiopogon japonicus,herba lophatheri,asarum,radix glehniae;fructus cnidii,madder,cortex moutan,acanthopanax bark,tribulus terrestris,fructus kochiae,etc.1.4 With the “frequency analysis” of syndromic types,the 338 cases showed 103 symptoms,where a total of 18 symptoms occurred in more than 10% times,With the most common symptoms being the joint pain,adverse joint flexion,thin white fur,pale tongue,thready pulse,chills,joint swelling,fatigue,lumbago,pink tongue.1.5Through the “cluster analysis” of symptoms,18 groups of core symptoms are obtained,including taut pulse,backache,night sweat;palpitations,chills,fatigue;no sweat,lumbago,cold,and thready pulse.Besides,based on unsupervised hierarchical clustering method,the core symptoms were integrated to obtain the final 8 new symptom combinations.1.6 Following the module of "case analysis" to "symptom analysis",and to "key symptoms",a total of 18 key symptoms were learnt with the top 10 as joint pain,adverse joint flexion,joint swelling,chills,thin white fur,cold,fatigue,dry mouth,pale tongue and thin pulse.The module of "key drugs" contributed a total of 18 key drugs,with the top 10 as cassia twig,licorice root,radices paeoniae alba,jujube,astragalus,atractylodes macrocephala koidz,poria,angelica,as arum,poria cocos,and saposhnikovia divaricata.Meanwhile,the "drug dosage analysis" was carried out to calculate the regular dosage of these drugs. 1.7 With the analysis of "medical statistics" and "syndrome statistics",anemofrigid-damp arthralgia,Qi and blood deficiency,syndrome of cold-dampness due to kidney deficiency,moist heat arthralgia spasm syndrome,cold-heat complicated syndrome turned out to be the most common symptoms in the total 338 cases.1.8 Based on the analysis of "medical statistics" and "syndrome statistics",the prescription in the total 338 cases were concluded,where the most commonly used prescriptions are as follows: Buzhong Guizhi Decoction,Guizhi Fuzi Decoction,Yupingfeng Guizhi Decoction,Chaige Guizhi Decoction,Huangqi Fangji Decoction and Zhuyeshigao Decoction.1.9 Based on the distribution of syndrome,"medical statistics" to "syndrome statistics" are carried out to learn the relationship between prescription and syndromes.Rheumatism caused by wind-cold-damp arthralgia is usually treared with Yupingfeng-Guizhi Decoction,Huangqi Fangji Decoction,Chaige-Guizhi Decoction or Fuzi-Guizhi Decoction.Besides,Qi and blood deficiency is usually treated with Buzhong Guizhi Decoction.1.10 “prescription and syndromes analysis” to “network display” function were used to obtain the "medicine-symptom network","medicine-syndrome network " and "medicine-syndrome-symptom network".2.Professor Wu Shengyuan believes that the occurrence of impediment disease is related with Yang deficiency,Qi and blood interruption and deficiency in spleen and stomach as well as liver and kidney,He proposes to seize the timing of the disease to distinguish and treat the disease,so as to reinforce the healthy qi and eliminate the pathogenic factors.Conclusion:After years of clinical practice,Professor Wu Shengyuan has followed characteristics in the treatment of impediment disease,cautiously grasped pathogenesis to reinforce the healthy qi and eliminate the pathogenic factors,He emphasizes the importance of improving the state of meridian,Qi and blood stasis.At the same time,with a consideration of the regional characteristics of Yunnan,Professor Wu Shengyuan believes that Yang deficiency cannot be ignored as an important reason for the occurrence in this disease,He advocates warming yang to dredge collaterals in the treatment and simultaneously pay attention to harmonize Qi and blood,harmonize the spleen and stomach,clear heat and eliminate dampness,regulate the liver and supplement the kidney in his clinical treatment.The treatment based on the diffrentiation of syndrome.Another conclusion is that Professor Wu Shengyuan is skillful in medication,rational administration and make good use of acrid-release and bitter-downbearing therapy,He has perfectly grasped the treatment with both elimination and reinforcement cultivated unique experience in the treatment,which is worth learning.