| Purpose:The research is intended to observe the clinical efficacy about the method of soothing liver,invigorating spleen and nourishing blood in treating Hashimoto’s thyroiditis,and to evaluate the influences of the method on the patients with Hashimoto’s thyroiditis in the aspects of the changes of clinical symptoms and signs,thyroid function and thyroid autoantibodies(including TGAb and TPOAb)levels.Moreover,the results of the research may provide new thoughts for the treatment of Hashimoto’s thyroiditis through Chinese medicine.Methods:A total of 40 patients with the diagnosis of Hashimoto’s thyroiditis,and with normal thyroid function or subclinical hypothyroidism(4.2<TSH<10uIU/mL),meanwhile,with syndrome of liver depression and spleen deficiency were selected for this study.Methods were randomly divided into two groups.In the control group,20 patients were followed up for observation without any drug intervention;20 patients in the treatment group were treated with traditional Chinese medicine by the method of soothing liver,invigorating spleen and nourishing blood.The treatment duration for the two groups was 3 months.The thyroid function(including TSH,FT3,FT4)and thyroid autoantibodies(including TPOAb and TGAb)were measured before and after treatment in the two groups,and the degree of change in clinical symptoms and signs before and after observation was evaluated with the score of syndrome.All data was processed with the statistical software SPSS 20.0.Results:①Overall clinical efficacy:The overall effective rate was 70%in the treatment group and 10%in the control group.The overall clinical efficacy of the treatment group was significantly better than that of the control group(P<0.01).②Efficacy of TCM Syndromes:The total scores of TCM syndrome before and after treatment in the treatment group were 17.05 ±4.58 and 8.10±3.60,the total scores of TCM syndrome before and after treatment in the control group were 16.10 ± 5.10 and 16.25 ± 5.44.After 3 months of treatment,the TCM syndrome total scores of the treatment group improved significantly(P<0.01),and the TCM syndrome total scores of the control group had no significant difference(P>0.05).In the efficacy of TCM syndromes,the effective rate in the treatment group was 85%,and the effective rate in the control group was 15%.The efficacy of the TCM syndrome in the treatment group was significantly better than that in the control group(P<0.01).The treatment group was able to significantly improve the symptoms of swollen neck,oppressive feeling around the neck,fatigue,abnormal emotion,pain of liver meridian,abnormal stool,sigh,and dizziness(P<0.05 or P<0.01).In the control group,only the improvement of the abnormal emotion was more obvious(P<0.05).The treatment group had better improvement in the symptoms of swollen neck,oppressive feeling around the neck,fatigue,abnormal emotion,pain of liver meridian,abnormal stool,sigh,and dizziness than those in the control group(P<0.05 or P<0.01).③Thyroid function:There was no significant change in thyroid function(including TSH,FT3,FT4)before and after treatment in the treatment group and control group(P>0.05).Before and after treatment,there was no significant difference in the levels of TSH,FT3,and FT4 between the two groups(P>0.05).④Thyroid-associated autoantibodies:The TGAb level before and after treatment in the treatment group were 413.94 ± 380.82 and 284.78 ± 266.13,the TGAb level before and after treatment in the control group were 495.42 ± 456.06 and 685.87 ± 643.99.After 3 months of treatment,the TGAb level in the treatment group was significantly improved compared with before(P<0.01),but there was no significant change in the TGAb level in the control group(P>0.05).The TGAb level in the treatment group was improved compared with the control group.There was a significant difference between them(P<0.05).The TPOAb level before and after treatment in the treatment group were 349.67 ± 217.23 and 229.93 ± 161.50,the TPOAb level before and after treatment in the control group were 312.90± 211.44 and 375.80 ±207.15.The TPOAb level in the treatment group was significantly lower than before(P<0.01),but the TPOAb level in the control group was significantly higher than before(P<0.05).There was a difference between the two groups,the treatment group can significantly reduce TPOAb level(P<0.05).⑤Safety:There was no adverse reaction occurred in the control group or the treatment group during the course of treatment.Blood routine,liver function,renal function,etc.,safety indexes of each group were within the normal range before and after treatment.Conclusion:The method of soothing liver,invigorating spleen and nourishing blood in treating Hashimoto’s thyroiditis patients can significantly improve the clinical symptoms and signs,reduce thyroid autoantibodies levels.At the same time,there is no significant effect on thyroid function.On the whole,we can get the satisfactory and safe treatment effect. |
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