Effect Of Tropisetron Ang Dexamethasone On Postoperative Nausea And Vomiting In Patients With Breast Tumor

Objective:To observe the effect of prophylactic administration of tropisetron hydrochloride injection and dexamethasone sodium phosphate injection on postoperative nausea and vomiting(PONV)in patients with breast tumor,so as to provide reference for better prevention and treatment of short-surgery PONV.Methods:A total of 120 patients undergoing breast tumor resection under general anesthesia from Guangxi Medical University Affiliated Tumor Hospital were selected.Age 18~65,BMI 18~25kg/m~2,American Association of Anesthesiologists(ASA)I~II,adulthood Female patient.120 adult female patients were randomly divided into three groups(n=40).Group A(tropestron hydrochloride injection):0.06 mg/kg of tropisetron hydrochloride injection was injected from the peripheral vein at the end of surgery,group B(dexamethasone sodium phosphate injection):at the end of the surgery,0.1 mg/kg of dexamethasone was given from the peripheral vein,and group C:normal saline control group.The three groups before surgery were routinely induced with the same induction method.During the operation,intravenous compound inhalation anesthesia was used.Intravenously pumped remifentanil,propofol,and cisatracurium,and the anesthetic pattern of sevoflurane inhalation was maintained.Postoperative follow-up observations were performed to record the number of cases,incidence,and severity of PONV occurrence at three time periods(0 to 3 hours,3 to 12 hours,and 12 to 24 hours)after the end of surgery,and general information was recorded for perioperative fentanyl.The dosage of remifentanil,operation time and anesthesia time.Results:(1)The general data of three groups of patients included age,weight,height,and BMI,with no statistical difference(P>0.05).There was no statistical significance in perioperative fentanyl dose and remifentanil dose between operation time and anesthesia time(P>0.05).(2)In the three postoperative periods,comparing the three groups:0-3h,3-12h,the number and incidence of PONV in group A and B were lower than that in group C,and the difference was statistically significant(P<0.05).(3)Within 3 to 12 hours after operation,the incidence and severity of PONV in group A were lower than those in group B and C.The difference was statistically significant(P<0.05).(4)At 12to 24 hours after surgery,there was no statistical difference in the incidence and severity of PONV between the three groups(P>0.05).Conclusion:It is necessary for prophylactic use of antiemetic to prevent the occurrence of PONV in breast tumor surgery;0.1mg/kg dexamethasone injection can effectively prevent and treat the occurrence of PONV in breast tumor patients;compared with 0.1 mg/kg dexamethasone,the incidence of PONV at 0~3h、3~12h and the suppression of PONV at 3~12h after breast tumor surgery of 0.06 mg/kg tropisetron hydrochloride is better than 0.1mg/kg dexamethasone,But 12 to 24h after operation,the results are similar.