Correlative Analysis Of Serum Creatinine,blood Urea Nitrogen And Erythrocyte Parameters In Patients With Chronic Renal Failure

Objective: To study the relationship between red blood cell parameters and blood urea nitrogen and serum creatinine in patients with chronic renal failure,and to explore the relationship between renal anemia and renal function.Methods: Eighty-two patients diagnosed with chronic renal failure at Nanhua First Affiliated Hospital of Hengyang City were selected as the experimental group.In the same period,58 healthy patients(no diabetes,hyperlipidemia,hypertension,coronary heart disease,thrombosis)from the physical examination center of our hospital were selected as the control group.Detect red blood cell parameters [Hb,HBC,RBC,HCT,MCV,RDW,MCHC] and Kidney Function [blood urea nitrogen(BUN)and serum creatinine(Scr)].After finishing,statistical software was used to perform statistical analysis on the data,and the differences of red blood cell-related indexes during the subgroups of the experimental group,the control group and the experimental group were compared.The correlations between red blood cell related indicators and serum creatinine and urea nitrogen were analyzed.Results:1.Compared with the indexes in the experimental group and the control group,there were significant differences(p<0.01)in serum creatinine,urea nitrogen,RBC,Hb,HCT,and RDW after t-test.It can be seen that RBC,Hb,HCT,MCHC,MCV and other indicators decreased,and serum creatinine,urea nitrogen,and RDW increased.The difference between MCV and MCHC was not statistically significant(P>0.05).In the experimental group,the Hb,HCT,and RBC showed significant differences from each other in the 4th phase of the experiment,showing a gradual decrease from the CKD2 phase to the CKD5 phase(P<0.01).Significant difference,showing an upward trend(P <0.01),MCV and MCHC showed no significant difference(P> 0.05).2.Chronic renal failure patients with urea nitrogen negative correlation with RBC,HCT,MCHC,MCV,There was a positive correlation with RDW,with no significant difference(P>0.05).There was a negative correlation with Hb,and the difference was statistically significant(P<0.05).Serum creatinine in patients with chronic renal failure was negatively correlated with RBC and HCT,and positively correlated with MCV,RDW,and MCHC.There was no significant difference(P>0.05).There was a negative correlation with Hb,and the difference was statistically significant(P<0.05).Conclusions: 1.Compared with normal healthy people,patients with chronic renal failure have significantly higher serum creatinine,urea nitrogen,RDW,RBC,Hb,and HCT,while MCV and MCHC are not significantly different.2.In patients with chronic renal failure,RDW increased significantly with impaired renal function.RBC,Hb,and HCT decreased significantly,and MCV and MCHC did not change significantly.3.The urea nitrogen in patients with chronic renal failure was negatively correlated with RBC,HCT,MCHC,MCV,showing a positive correlation with RDW,and showing a significant negative correlation with Hb.4.Serum creatinine in patients with chronic renal failure was negatively correlated with RBC,Hb,and HCT,positively correlated with MCV,RDW,and MCHC,and showed a significant negative correlation with Hb.