| Objective: the characteristics of traditional Chinese medicine syndrome differentiation and treatment combined with modern medical objective examination indicators,the integrated TCM concept and modern medical technology,to explore the correlation between primary hyperlipidemia and carotid atherosclerosis degree,degree of fundus atherosclerosis and blood lipid level.According to the inclusion criteria were selected in our hospital 160 patients with primary hyperlipidemia,application of modern statistical methods,statistics and analysis of the clinical data,to study the correlation between carotid atherosclerosis degree,degree of fundus arteriosclerosis and conventional blood test indicators and primary hyperlipidemia syndromes,the syndrome differentiation of primary hyperlipidemia type is more scientific,objectivity.Methods:1.According to the inclusion criteria from the Second Affiliated Hospital of Dalian Medical University,inpatient and outpatient patients with primary hyperlipidemia 160,primary and secondary disease diagnosis system of Chinese medicine theory and application,and in accordance with the theory of TCM were divided into five clinical syndromes,including qi stagnation and blood stasis,spleen kidney yang deficiency,Yin deficiency of liver and kidney and sputum type,hyperactivity.2.The general situation of TCM,statistics and analysis of the patients with the main indexes,blood lipids(including triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A1(Apo A1),apolipoprotein B(Apo B)),according to the fundus arteriosclerosis grade of carotid intima-media thickness and ultrasound the degree of carotid stenosis,fundus microscope,and then the control analysis of the indicators with primary hyperlipidemia types,explore the correlation between.3.Data statistics: the measurement data is expressed as mean(x)+ standard deviation(s).All statistical tests were two-sided test,the test level alpha was 0.05,the data were analyzed by variance analysis,and the data were analyzed by chi square test.The SNK test was used to compare the data between the two groups.All statistics are SPSS 21,tabulation software using Excel 2003.Results: Statistics and analysis of the clinical data of 160 cases of primary hyperlipidemia patients,found sputum type TC and LDL-C were significantly increased(P<0.05),Apo A1,Apo A1/Apo B were significantly decreased(P<0.05);TC LDL-C,qi stagnation and blood stasis type were significantly increased,while Apo A1,Apo A1/Apo the level of B was significantly decreased(P<0.05).There was no significant difference in carotid intima media thickness(CIMT),plaque formation and degree of stenosis in patients with primary hyperlipidemia and carotid artery atherosclerosis(P>0.05).Comparison of primary hyperlipidemia syndromes and the degree of correlation degree of fundus arteriosclerosis,fundus hardened phlegm obstruction patients with grade IV(P<0.05);the degree of fundus changes of cirrhotic patients with hyperactivity of Yang due to yin deficiency,qi stagnation and blood stasis type is dominated by III change(P<0.05);degree of fundus hardening of spleen kidney yang deficiency patients with grade I and III level(P<0.05);the degree of fundus arteriosclerosis of yin deficiency of liver and kidney were dominated by I change(P<0.05).Conclusion: The level of blood lipid and fundus artery hardening can be used as a primary clinical diagnosis of hyperlipidemia type reference,degree of carotid atherosclerosis can not be used as the primary hyperlipidemia syndrome type reference,the level of blood lipid and fundus artery atherosclerosis can provide a reference basis for the objective evaluation for clinical diagnosis of primary hyperlipidemia type.Therefore,there is a scientific bridge between TCM syndrome differentiation and clinical objective indicators of primary hyperlipidemia,which is worthy of further clinical research and discussion. |
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