A Clinical Efficacy On Chronic Atrophic Gastritis Treated With Professor Li Zhenhua’s Theory Of Dynamic Differentiation And Its Effect On Serum EGF

Objectives:1.To study the improvement of the clinical symptom score and the gastric mucosa pathological changes of the patients before and after the treatment,and to elucidate the clinical effect of the Xiang Sha wen Zhong Tang(traditional Chinese medicine)established by Mr.Li Zhenhua through the spleen-stomach liver dynamic syndrome differentiation method on the patients with chronic atrophic gastritis(CAG),spleen and stomach Qi(yang)deficiency,stagnation of the liver and stomach hysteresis syndrome.2.Observing the change of serum EGF concentration after treatment in patients with chronic atrophic gastritis(CAG),spleen and stomach Qi(yang)deficiency,stagnation of the liver and stomach hysteresis syndrome in the treatment group and the control group.Discuss the possible mechanism of the effect of the Xiang Sha wen Zhong Tang(TCM)on the disease.METHODS: A total of 70 patients who met the inclusion criteria of this study and excluded who met exclusion criteria and those were selected as the subjects.Randomly assigned 35 patients into the treatment group and control group respectively.6 months for one course of treatment.After one course of treatment,statistically record the two groups before treatment and after treatment of symptom’s total integral and TCM’s symptom curative effectt.Simultaneously record the changes of the mucosal tissue under gastroscope and pathology changes.Observe two groups before and after treatment on the improvement of their clinical symptom integral and pathological changes of gastric mucosa tissue under gastroscope,organize data,statisticallyrecord and analysis.The treatment group was treated with the Xiang Sha wen Zhong Tang(TCM),1dose / day,decoction 400 ml,take it in the morning and evening each time 200 ml,course of treatment was 6 months.The control group was treated with oral medicine,Wei Fu Chun tablet(TCM),4tablets each time,3 times a day,the course of treatment was 6 months.Patients who met the inclusion criteria were Extracted venous blood 4ml on an empty stomach before and after treatment.The serum concentration of EGF was detected by ELISA method.The changes of the values in the treatment group and the control group were analyzed and compared,and the data were collected and analyzed statistically.Results: 1.After treatment,the treatment group and the control group’s total points of symptoms were reduced before the treatment,the difference was statistically significant(P<0.05).It was suggested that the two groups were able to improve the clinical discomfort symptoms of CAG patients;the total score difference of the two groups after symptom treatment was compared,P<0.05,suggesting that the treatment group could improve the discomfort symptoms of the patients better than the control group.In the treatment group and the control group,the curative rate was 72.73%and40.63%(P<0.05)by statistical analysis,and the total effective rate was 96.97%and59.38%(P<0.05).2.After treatment,the cure rate of gastric mucosa atrophy in the treatment group was 69.70%,the control group was 37.50%,and the treatment group was superior to the control group(P<0.05).The total effective rate of the two groups of gastric mucosa atrophy was 75.76% and 46.88%,respectively,and the treatment group was superior to the control group(P<0.05).3.After treatment,the cure rate of intestinal metaplasia in the gastric mucosa of the treatment group was 48%,the control group was 20.83%,P<0.05,suggesting the difference was statistically significant.The total effective rate of the intestinal metaplasia in the treatment group and the control group was 60%,29.17%respectively,P<0.05,suggesting that the difference was statistically significant.4.After treatment,the concentration of EGF in the serum of the treatment group and the control group was reduced compared with that before treatment,and the difference was statistically significant(P<0.05).After treatment,the difference of serum EGF concentration comparison between the treatment group and the control group,P<0.05,indicating that the treatment group was better than the control group in decreasing EGF concentration level.5.Of all the 65 cases included,there were 2 cases of dysplasia in the gastricmucosa,due to limited sample size and lack of verifiability,the description and statistical analysis were not carried out in the article.6.No obvious adverse reactions occurred during the experiment.Conclusion:the Xiang Sha wen Zhong Tang(TCM)can improve the clinical discomfort symptoms of CAG,spleen and stomach Qi(yang)deficiency,stagnation of the liver and stomach hysteresis syndrome,reduce or reverse the histopathological changes of atrophy and intestinal metaplasia,reduce the level of EGF,and the curative effect is better than that of Wei Fu Chun(TCM).