Clinical Observation On Treatment Of Small Follicle Ovulation Infertility With Kidney Deficiency And Liver Depression With Deshengdan

Objective:To observe the intervention effect of Deshengdan on small follicle ovulation infertility,the clinical pregnancy rate,the size of dominant follicle on ovulation day,the thickness of endometrium and the level of serum estradiol（E2）were observed.Objective analysis of TCM syndrome and other clinical indicators,comprehensive evaluation of the clinical efficacy of Deshengdan in small follicular ovulation infertility,and explore the mechanism of its action.Methods:80 patients with small follicle ovulation infertility who met the criteria of this study were randomly divided into treatment group（n=40）and control group（n=40）.There was no significant difference in course of disease and general information related to disease（P>0.05）.The treatment group was treated with Chinese medicine Deshengdan and the control group only with clomiphene.The patients in both groups were treated for 3 months（1 course of treatment）.By observing the clinical pregnancy rate of the two groups,the diameter of dominant follicles,the thickness of endometrium,the serum E2 level in luteal phase,clinical symptoms and signs were analyzed statistically before and after ovulation.To evaluate the clinical efficacy of traditional Chinese medicine in the treatment of follicle ovulation infertility.Results:Firstly,comparison of TCM syndromes:after treatment,the symptom scores of the two groups were all decreased,and the improvement of TCM syndromes in the two groups was more obvious than that in the control group（Deshengdan and CC）（P<0.05）.The curative effect of TCM syndrome in the treatment group was better than that in the control group（P<0.05）.Then,the laboratory indexes were as follows:the diameter of dominant follicles was increased in both groups on ovulation day（P<0.05）,but the treatment group had more advantages than the control group.Comparison of endometrial thickness:the treatment group increased the endometrial thickness（^△P₁<0.05）,the control group had little effect on the endometrial thickness（^△P₂>0.05）,and the E2 level of thetreatment group increased on the ovulation day（^△P₁<0.05）.There was no significant change in E2 on the day of ovulation in the exposure group（^△P₂>0.05）.At last,the pregnancy rate was 33.33 in the treatment group and 10.52 in the control group.The pregnancy rate of the two groups was significantly higher than that of the control group（P<0.05）.Conclusion:Deshengdan combined with clomiphene（CC）is effective in the treatment of ovulation of small follicles,which can improve pregnancy rate,increase endometrial thickness,optimize follicles shape,increase the diameter of dominant follicles,increase the level of E2 hormone,and improve the TCM syndrome of the patients.There were no adverse events during the study.Deshengdan was safe and effective in the treatment of follicular ovulation.