The Clinical Significance Of NLR And PLR In Children With Sudden Hearing Loss

Objective: In this study,neutrophilic lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)were calculated to clarify the etiological clues of inflammation related to the occurrence of sudden deafness in children.To investigate the clinical significance of NLR and PLR as novel serum biomarkers in the pathogenesis of sudden deafness in children and their prognostic value.Methods:Due to the low incidence of sudden deafness in children,32 cases and 30 cases of sudden deafness in the sudden deafness group were selected from the two hospitals where I worked as an intern.The international convention on the rights of the child defines a child as anyone under the age of 18.Before the treatment,all children with sudden deafness received pure tone audiometry,blood routine and other relevant examinations,and NLR and PLR were calculated according to the diagnostic standard classification of sudden deafness.After the treatment,the patient reexamined the pure tone audiometry and recorded the hearing changes.35 and 32 healthy subjects were selected as the control group in the two hospitals.Patients with sudden deafness were divided into two groups according to treatment effect: recovery group and non-recovery group,and peripheral blood NLR,PLR,white blood cell count,neutrophil absolute value,lymphocyte absolute value and platelet count of the two groups were compared.Mean standard deviation(SD)was used to represent age,NLR,PLR,white blood cell count,absolute neutrophil,lymphocyte,monocyte,eosinophil,basophil,platelet count and mean platelet volume(MPV)between the two groups.Double-tailed t-test and chi-square test were used to assess clinical features and possible prognostic factors.Results: The mean value of NLR of children with sudden deafness in the two hospitals was 2.70 ±0.90 and 2.8± 1.22,respectively.The NLR of the control group was 1.51± 0.36 and 1.29 ±0.23,respectively.The comparison between the sudden deafness group and the control group was statistically significant(p<0.01).The PLR of the sudden deafness group in the two hospitals was 138.79 ±39.56 and 140.47 ±39.22,respectively.The PLR of the control group was 111.7± 30.72 and 105.68 ±17.47,respectively.The comparison between the sudden deafness group and the control group was statistically significant(p<0.01).The white blood cell count and the absolute value of neutrophils in the sudden deafness group of the two hospitals were significantly higher than those in the control group,while the absolute value of lymphocytes was lower than that in the control group.The data of the two groups were statistically significant(p<0.01).There was no significant difference in MPV between the sudden deafness group and the control group(p>0.05).The mean value of NLR in the unrecovered group was 3.49± 0.82 and 3.61± 1.37,and the NLR in the recovered group was 2.09 ±0.22 and 2.17± 0.6,respectively.The NLR in the unrecovered group was higher than that in the recovered group,and the difference between the two groups was statistically significant(p<0.05).The PLR of the unrecovered group was 154.26 ±33.99 and 154.5 ±33.93,respectively,and the PLR of the recovered group was 127.19 ±38.13 and 129.75±40.53,respectively.The PLR of the unrecovered group was higher than that of the recovered group,but there was no statistical significance(p>0.05).The absolute value of neutrophils in the unrecovered group was significantly higher than that in the recovered group,while the absolute value of lymphocytes in the unrecovered group was lower than that in the recovered group,which was statistically significant(p<0.05).Conclusion: 1.NLR in children with sudden deafness is significantly higher than that in normal children,suggesting that NLR is significantly related to the onset of sudden deafness,and that NLR is closely related to prognosis,which supports the etiological theory of chronic inflammation in children with sudden deafness.Therefore,peripheral blood NLR can be used as a more valuable,simple and reliable serum biomarker to predict the prognosis of sudden deafness in children.2.The relationship between PLR and prognosis in children with sudden deafness has not been found,which is different from that in adults.There was no increase in MPV in the sudden deafness group,which was also different from that in adults.It is suggested that the pathogenesis of children may be different from that of adults,and most of them are not closely related to the blood agglutination state.3.The analysis results of case studies in the two hospitals are consistent,indicating that different types of machines meet the clinical standards,and the results are consistent,further suggesting the credibility of this ratio.