Clinical Observation Of Jinguibaoxin Mixture In The Treatment Of Arteriosclerosis Occlusion Of Lower Limbs(syndrome Of Blood Stasis)

Objective: This subject mainly studies the treatment of arteriosclerosis occlusion of lower limbs,which is classified as blood stasis syndrome.By applying the changchun university of Chinese medicine affiliated hospital hospital preparations of gold to protect heart mixture to treat disease of lower extremity arteriosclerosis occlusion(blood stasis resistance)of the patients,to observe the clinical efficacy and safety,to lower limb arteriosclerosis occlusion disorder(blood stasis resistance)of treatment of traditional Chinese medicine to provide new idea and effective method.Methods: Based on clinical observation,this study selected 72 patients who met the diagnostic criteria and inclusion criteria from the heart disease outpatient department,heart disease treatment area and heart disease CCU ward of the affiliated hospital of changchun university of traditional Chinese medicine.Using random number table method,36 cases were divided into experimental group and control group.After 2 groups of patients were enrolled and given corresponding basic treatment,36 patients in the experimental group were given jingui baoxin mixture(60ml/ bottle,affiliated hospital of changchun university of traditional Chinese medicine),20 ml each time,3 times a day for oral administration,and36 patients in the control group were given cilotazole tablets(50mg/ tablet,zhejiang otsuka pharmaceutical co.,LTD.),50 mg each time,2 times a day for oral administration.During the trial,drugs other than cilotazole tablets and jingui baoxin mixture for the treatment of arteriosclerosis occlusion of the lower extremities or peripheral artery dilation were prohibited.The improvement of TCM syndromes,ankle-brachial index(ABI),and popliteal artery inner diameter of the two drugs were observed at 3 months before and after treatment,respectively,and the clinical efficacy and safety were evaluated.SPSS 20.0 statistical analysis software was used to calculate the final statistical significance of the physical and chemical examination results and efficacy evaluation indexes collected in the whole study process.Results:1.Comparison of curative effect of TCM syndromes: after 3 months of effective treatment,both groups can improve TCM syndromes of patients.The total effective rate of the experimental group was 93.4%,and that of the control group was 75.0%.The comparison of the efficacy of TCM syndrome after treatment between the two groups was statistically significant(P=0.022 < 0.05).Jinguibaoxin mixture is superior to silotazole in improving the TCM syndrome of arteriosclerosis occlusion of lower limbs(blood stasis syndrome).2.Ankle-brachial index comparison: after 3 months of treatment,the patients’ ankle-brachial index was improved in both groups.There was no statistically significant difference between the experimental group and the control group before treatment(P=0.391 > 0.05),while there was statistically significant difference between the experimental group and the control group after treatment(P=0.015 < 0.05).Jinguibaoxin mixture was superior to silotazole in improving the ankle-brachial index of patients with arteriosclerosis occlusion of lower limbs(blood stasis syndrome).3.Comparison of popliteal artery diameter: after 3 months of standardized treatment,the popliteal artery diameter of patients in both the jingui baoxin mixture group and the silotazole tablet group could be effectively expanded.There was no statistically significant difference between the experimental group and the control group before treatment(P=0.777 > 0.05),and no statistically significant difference between the experimental group and the control group after treatment(P=0.111 > 0.05).That is,the experimental group has no advantage over the control group.4.security index comparison: before and after treatment for 3 months respectively to check two groups of patients’ body temperature,pulse,heart rate,blood routine(including white blood cells,red blood cells,hemoglobin and platelets),routine urine,urine protein,urine red blood cells),liver function(Alt,aspertate aminotransferase)and renal function(serum creatinine,serum urea nitrogen),found no obvious abnormalities.After treatment,there was no significant difference between the two groups(P > 0.05).There was no significant difference in the safety between the two groups,and the two groups were safe in clinical application.Conclusion: Jinguibaoxin mixture was used in the affiliated hospital of changchun university of traditional Chinese medicine for the treatment of arteriosclerosis occlusion of lower limbs(blood stasis syndrome).It can effectively improve the TCM syndrome of the patient,improve the ankle brachial index of the patient,and expand the popliteal artery vascular diameter of the patient.