The Clinical Observation In The Treatment Of Kidney Deficiency And Blood Stasis Type Of ACA(+)RSA By Combination Of Chinese Traditional And Western Medicine

Objective:To observe the clinical efficacy of Bushen Huoxue decoction combined with small dose of aspirin and low-molecular-weight heparin calcium(LMWHC)in the treatment of kidney deficiency and blood stasis type of ACA(+)RSA,and to explore its mechanism and advantage,so as to provide theoretical support and scientific basis for clinical application.Methods:(1)90 cases of RSA patients with kidney deficiency and blood stasis type of ACA(+)were randomly divided into three groups that each group own 30 cases,traditional Chinese medicine combined with western medicine observation group,the western medicine control group and the traditional Chinese medicine control group.(2)The observation group was treated with Bushen Huoxue decoction combined with small dose of aspirin and LMWHC;the western medicine control group was given small dose of aspirin and LMWHC;the traditional Chinese medicine control group was given Bushen Huoxue Decoction;(3)The treatment continues 3 menstrual cycles,and then the clinical efficacy of three groups was analyzed by observing the proportion with ACA(-),the6-PGFIα,the anticoagulant PC,PS,the traditional Chinese medicine symptoms and the rate of platelet aggregation.Results:(1)Incidence of cases: 90 cases were collected,30 cases in each group.3cases in the Chinese and Western medicine observation group did not recheck during the prescribed time.2 patients in the western medicine control group did not take the medicine as required and 1 patient did not follow the prescribed time.In traditional Chinese medicine control group,2 patients were not reviewed.In conclusion,there were 27 cases in observation group,27 cases in western medicine control group,28 cases in traditional Chinese medicine control group.(2)The age,ACA negative rate,the 6-PGFIα,the anticoagulant PC,PS,the traditional Chinese medicine symptoms,the rate of platelet aggregation,and the D-dimer before treatment were statistically analyzed in the three groups.There was no statistically significant difference between the three groups.(3)After treatment,the traditional Chinese medical syndromes of three observation groups all decreased.The effective rate was 88.89% in the observation group,the western medicine control group was 70.37%,and the effective rate the traditional Chinese medicine control group was 85.72%.The observation group was better than the western medicine controlgroup and the traditional Chinese medicine control group.The traditional Chinese medicine control group was better than the western medicine control group,which showed significant differences between them in the aspect of improving the traditional Chinese medical syndromes after treatment(P<0.05).(4)The proportion of ACA(-)in observation group was 77.78%,the proportion of ACA(-)in the western medicine control group was51.85%,and the proportion of ACA(-)in the control group of traditional Chinese medicine was 67.86%.(5)The 6-PGFIα increased in the three groups after treatment,and the differences were statistically significant(P<0.05).(6)After treatment,the platelet aggregation rate of the three groups decreased,and the differences were statistically significant(P<0.05).(7)After treatment,the anticoagulant PS increased in the three groups,and there was statistically significant difference(P<0.05).(8)After treatment,the platelet aggregation rate of three groups decreased,and the differences were statistically significant(P<0.05).(9)The total effective rate of the observation group was 81.48%,the western medicine control group was 66.67%,and the traditional Chinese medicine control group was 71.43%.The comprehensive curative effect of the observation group is the better than the group of western medicine and traditional Chinese medicine control group.The traditional Chinese medicine group is better than the western medicine control group.There were no obvious adverse reactions during the three groups.Conclusion:(1)The therapy of Bushen Huoxue decoction combined with small dose of aspirin and LMWHC is better than the therapy of small dose of aspirin combined with LMWHC or the therapy of Bushen Huoxue decoction.In improving the rate of RSA(-)and TCM syndromes,it is superior to simply use traditional Chinese medicine or western medicine,and is worthy of clinical promotion and application.(2)The effect of simple use of Bushen Huoxue decoction in the treatment of kidney deficiency and blood stasis type of ACA(+)RSA is better than the small dose of aspirin combined with LMWHC.(3)The therapy of Bushen Huoxue decoction has advantages in improving the TCM syndrome and ACA negative conversion rate compared with the use of low-dose aspirin and LMWHC.(4)The small dose of aspirin combined with LMWHC is superior to the use of Bushen Huoxue decoction alone in improving 6-PGFIα,the anticoagulant PC,PS and the rate of platelet aggregation.(5)The therapy of Bushen Huoxue decoction combined with small dose of aspirin and LMWHC is safe and effective in the treatment of kidney deficiency andblood stasis type of ACA(+)RSA.