The Clinical Curative Effcet Observation Of Insomnia(phlegm-heat Disturbance)treated By ChaiQinWenDan Particles

Objective:The purpose of this study is to initially observe the clinical efficacy of Chaiqi Wendan particles in the treatment of insomnia with phlegm-heat disturbance,and to improve the status of syndromes in traditional Chinese medicine,and to explore the advantages and safety of Chaiqi Wendan Particles in the treatment of insomnia with phlegm-heat disturbance.Methods:80 cases of insomnia patients collected at the clinic,meeting the inclusion criteria of Chinese and Western medicine,were randomly assigned to Chaiqi Wendan particles group(abbreviated as treatment group)and Baicaoxiang Jieyu Anshen Capsules Group(abbreviated as control group)according to the number of visits and random number table method.In each group of 40 patients,the treatment group was treated with Chaiqin Wendan particles,and the control group was treated with Baicaoxiang Jie Anshen Capsules for 8 weeks.The Pittsburgh Sleep Quality Index scale scores before and after treatment were observed in the two groups.Changes in clinical symptoms,syndrome scores and other indicators,all data were analyzed using SPSS 22.0.Results:Before treatment,the gender,age,marital status,education level,disease course,and related efficacy indexes of the two groups of patients were statistically analyzed and compared,and the difference was not statistically significant(P>0.05).The results were comparable.After 8 weeks of treatment:1.Pittsburgh Sleep Quality Index(PSQI)table scores: After treatment,the PSQI scores of the treatment group and control group were lower than those before treatment,and the difference was statistically significant(P<0.05).All had good therapeutic effect;the PSQI scores of the comparison group were lower than the control group(P<0.05),and the treatment group was better than the control group.The PSQI scores of the two groups were improved to some extent from the baseline(P<0.05).After treatment,the treatment group was significantly better than the control group in terms of daytime functional improvement(P<0.01),and the residual disease was significantly better than the control group(P<0.05).2.Comparison of TCM syndromes: The total effective rate of TCM syndromes was87.18%;the total effective rate was 73.68% in the control group.The Z-test(P<0.05)showed statistically significant difference.The TCM syndrome of the treatment group was significantly superior.In the control group,the total scores of the two groups of TCM syndromes before and after treatment were compared(P<0.05).The difference was statistically significant.After the treatment,the symptom scores of the two groups were lower than those before the treatment.Both groups had good curative effect;There was a statistically significant difference between the two groups in the total groups of TCM syndromes(P<0.05),and the treatment group was superior to the control group.3.Safety: After treatment 4 w and 8 w,only a few patients in the two groups had mild adverse reactions and could relieve themselves.No other adverse events and serious adverse events occurred during the treatment.Conclusion : 1.For the treatment of patients with insomnia and heat disturbance,Chaiqi Wendan particles and Baicaoxiang Jieyu Anshen Capsules have good therapeuticeffects compared with the control group;2.Chaiqi Wendan particles have obvious advantages in improving sleep disturbance,dreaminess,upset and annoyance,mouth pain,chest tightness,palpitations,five symptoms of traditional Chinese medicine and daytime dysfunction in patients with insomnia;3.In the treatment of patients with insomnia,fever,and internal disturbance,Chaiqin Wendan particles group and Baicaoxiang Jieyu Anshen capsules group all have good safety,and patients have better compliance.