Clinical Study On Chaihu Guizhi Ganjiang Decoction For "Shaoyang Taiyin Hanre" Diarrhea Irritable Bowel Syndrome

Objective:To observe the clinical efficacy and safety of Chaihu Guizhi Ganjiang Decoction in the treatment of diarrhea-type irritable bowel syndrome(IBS-D)of "Shaoyang Taiyin Hanre".Methods:Using a randomized controlled approach 70 patients with IBS-D were included according to the inclusion and exclusion criteria,and were randomly divided into observation group and control group.The two groups of patients were adjusted for daily living,improving diet structure,psychological counseling and other general treatment.On the basis of general treatment,the observation group was given oral Chinese medicine "Chaihu Guizhi Ganjiang Decoction",and the control group was given oral western medicine "Trimebutine Maleate Tablets".both groups were treated for 4 weeks.After 4 weeks of treatment,the TCM syndrome scores,abdominal pain diarrhea response rate,IBS-SSS score,quality of life score and safety indicators were observed in the two groups,and statistical analysis was performed to evaluate the efficacy and safety of Chaihu Guizhi Ganjiang Decoction in the treatment of "Shaoyang Taiyin Hanre" IBS-D Result:1.A total of 70 patients were enrolled in the study,of which 65 patients completed clinical observation,3 patients were fall off from the observation group,2 patients were fall off from the control group,and the total shedding rate was 7.14%.2.Baseline data comparison: There was no significant difference in gender,age,disease duration,and TCM syndrome distribution between the two groups(P>0.05),which was comparable.3.In terms of TCM syndrome efficacy:(1)After 4 weeks of treatment,the total effective rate of the observation group was 90.63%;the total effective rate of the control group was 69.70%,and the efficacy and total effective rate of the observation group were better than the control group(P<0.05).(2)The total scores of TCM syndromes in the two groups were lower than those before treatment(P<0.05),and the observation group was superior to the control group(P<0.05).(3)In terms of TCM syndrome single points,the scores of all symptoms in the observation group were lower than those before treatment(P<0.05).There was no significant difference in the scores of the control group before and after treatment in the cold limbs(P>0.05),but the scores after treatment were lower than before treatment in other symptoms(P<0.05),After treatment,there was no significant difference in Post-treatment score between the two groups in terms of abdominal pain,diarrhea,frequency of bowel movements,unpleasantness after diarrhea,etc.(P>0.05);In the aspects of emotional depression or irritable irritability,mouth pain,chest pain,and limbs,the Post-treatmen scores in the observation group were lower than those in the control group(P<0.05).4.In the response rate of abdominal pain and diarrhea: after 4 weeks of treatment,the abdominal pain response rate and diarrhea response rate of the observation group were 75.00% and 68.75%,respectively,which were higher than 48.48% and 42.42% of the control group,and there were statistical differences(P<0.05).5.In terms of IBS-SSS efficacy: After 4 weeks of treatment,the observation group was markedly effective in 9 cases,effective in 19 cases,ineffective in 4 cases,control group markedly effective in 3 cases,effective in 22 cases,and ineffective in 8 cases.The observation group was superior to the control group(P< 0.05).The total effective rate of the observation group was 87.5%,and the total effective rate of the control group was 75.76%.There was no statistical difference between the two groups.In terms of IBS-SSS scores,the total scores after treatment were lower than those before treatment(P<0.05),and the observation group was superior to the control group(P<0.05).6.In terms of quality of life scores: both groups improved the quality of life of patients(P<0.05),and the observation group was superior to the control group(P<0.05).7.In terms of safety and adverse reactions:The two groups of patients had blood routine,urine routine,stool routine + OB,electrolyte,liver and kidney function,electrocardiogram and abdominal color Doppler examination before and after treatment,and no clinically significant abnormal changes were observed.Conclusion:Chaihu Guizhi Ganjiang Decoction for the treatment of "Shaoyang Taiyin Hanre" diarrhea-type irritable bowel syndrome,can significantly improve the TCM syndrome scores,abdominal pain diarrhea symptoms,IBS-SSS score and quality of life score of patients,the clinical effect is exact,in the improvement of patients with extraintestinal symptoms has obvious advantages,and it has good security.