| Purpose:In order to observe the effect of Qiyangyuyin granules on insomnia of Yin-deficiency and fire-type syndrome in hypertensive patients.To provide a new way to treat hypertension patients with insomnia.Method:From September 2019 to February 2020,60 patients with hypertension and insomnia are chose for the researth.They were from hypertension research institute and department of cardiology of Jiangsu Province Traditional Chinese Medicine Hospital.They were randomly divided into two groups,each with 30 cases.The blood pressure of the two groups was controlled in accordance with the conventional hypotensive methods of medicine,so that the blood pressure reached the standard(lower than 140/90mmHg).If the standard was not reached after 4 weeks,they could not be included in the group.In the control group,Tianwangbuxinwan were used to improve sleep on the basis of western medicine to reduce blood pressure,while in the treatment group,Qianyangyuyin granules were used on the basis of western medicine to reduce blood pressure.Both groups were observed for 8 weeks.Observe and record of two groups of patients with PSQI score,ISI score,HAMA score,heart rate variability index,clinical symptoms,TCM syndrome score,clinic blood pressure,using SPSS 19.0,evaluate the efficiency of Qianyangyuyin granules on hypertension patients with insomnia.Result:Affected by the COVID-19 at the beginning of 2020,7 persons withdrew from the study,a total of 53 persons were eventually included in this study,including 28 in the treatment group and 25 in the control group.Each group has 23 persons do the heart rate variability text.1.Comparison of PSQI scores:After treatment,except for the control group,sleep efficiency was not significantly improved before and after treatment(P>0.05),scores and total scores of all dimensions were significantly improved after treatment than before treatment in the two groups,and the difference was statistically significant(P<0.01).After treatment,the sleep quality score of the treatment group was lower than that of the control group(P<0.05),and the score of daytime dysfunction was significantly lower than that of the control group(0<0.01).In other dimensions and total scores,the treatment group showed a downward trend compared with the control group,but there was no statistical difference.2.Effective rate of insomnia:After rank-sum test,the effective rate of insomnia in the two groups was P=0.033<0.05,which was statistically significant.3.ISI score results:The ISI score of the treatment group and control group improved significantly after treatment compared with that before treatment,and the difference was highly statistically significant(P<0.01,P=0.01).After treatment,the ISI score of the treatment group was lower than that of the control group(P<0.05).4.HAMA score results:After treatment,HAMA score in the treatment group and the control group was significantly improved compared with that before treatment,and the difference was highly statistically significant(P<0.01).After treatment,there was no significant difference between the treatment group and the control group(P>0.05)5.Heart rate variability indicators:SDNN and PNN50 in the treatment group were significantly higher after treatment than before treatment,with statistically significant differences(P<0.05).Compared with the control group before and after treatment,some indicators also showed an upward trend,but the difference was not statistically significant.There was no significant difference between the groups after treatment(P>0.05).6.Clinic blood pressure:Systolic blood pressure of the treatment group decreased significantly after treatment compared with that before treatment on the premise that the basic hypotensive blood pressure had reached the standard,with a statistically significant difference(P<0.01).Diastolic blood pressure after treatment decreased compared with that before treatment,but there was no statistically significant difference(P>0.05).Systolic and diastolic blood pressure in the control group decreased after treatment compared with that before treatment,but there was no significant difference(P>0.05).After treatment,compared with the blood pressure between the groups,systolic blood pressure of the treatment group decreased significantly(P<0.05),and diastolic blood pressure level was not significantly different between the two groups(P>0.05).7.TCM syndromes of insomnia:Before treatment,all TCM syndromes of patients in the two groups were>0.05 by independent sample T test,showing no statistical significance and comparable.After treatment,all symptoms except forgetfulness,tongue and tongue coating were significantly improved in the treatment group.Paired sample T test showed P<0.01,which was statistically significant.Compared with the control group before treatment,the patients in the control group were all improved by the paired sample T test(P<0.01 or P<0.05).After treatment.compared with the control group,the scores of TCM syndromes of insomnia in the treatment group decreased significantly,which was mainly reflected in the improvement of pain and weakness of the waist and knee,wakefulness of dreams,dizziness and tinnitus(P<0.01,P<0.05).Conclusion:1.In this study,the effect of Qianyangyuyin granules on insomnia in patients with hypertension was studied.Compared with the effect of Tianwangbuxinwan on improving sleep,Qianyangyuyin granules could better improve sleep quality,daytime dysfunction and severity of insomnia in patients.2.While improving sleep,Qianyangyuyin granules can also assist western medicine to reduce blood pressure,especially for systolic blood pressure.Tianwangbuxinwan have a tendency to improve blood pressure while improving sleep,but there is no statistical significance.The improvement of blood pressure by Qianyangyuyin granules is obviously better than that by Tianwangbuxinwan.3.Qianyangyuyin granules can better improve patients’ TCM syndromes and reduce their clinical symptoms,which is worthy of clinical promotion.4.For the insomnia of Yin-deficiency and fire-flourishing syndrome in hypertensive patients,focus on the treatment of liver and kidney,nourishing kidney to nourishing liver.and to clear the liver heat,nourishing Yin and clearing the heat,balance Yin and Yang,can also help sleep. |
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