Syndrome Differentiation Research Based On Mycoplasma Pneumonia In Children

Objective: By way of data mining of large sample and multi-center clinical data of mycoplasma pneumonia in children,research on syndrome differentiation of febrile diseases and fever have been carried out,in order to inspire the application of determination of stagnated heat syndrome,deepen the research on the theoretical system of syndrome differentiation and treatment of febrile diseases and promote the theory of doctrine of epidemic febrile disease research and application and its subject development.Methods: From January 2017 to December 2018,children of Mycoplasma pneumonia from total 3 hospitals in Beijing Children’s Hospital affiliated to Capital Medical University,Nanjing Hospital of Traditional Chinese Medicine and First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine were collected,total 493 cases.Four diagnostic methods information of clinical cases were extracted,then a total database was established.The secondary database was set up according to the method with syndrome differentiation of stagnation heat syndrome.Among them,the secondary database of 83 cases of Weifen intangible stagnation heat syndrome,the 121 cases of Qi invisible stagnation heat syndrome,142 cases of phlegm heat stagnation syndrome,64 cases of muggy syndrome and 46 cases of dry stools stagnated-heat syndrome were analyzed and used the method of associated rule,combined analysis result and understanding of the basic theory of traditional Chinese medicine and the syndrome differentiation method of doctrine of epidemic febrile disease,conducting research on syndrome differentiation of stagnated heat syndrome of children with mycoplasma pneumonia,and summarizing and understanding the stagnated heat syndrome differentiation methods of febrile diseases.Result: 1.The frequency analysis results of each syndrome type showed that:(1)The four methods of diagnosis information with high frequency of 83 cases of Wei phrase invisible stagnation heat syndrome is: cough,fever,low phlegm quality,rapid pulse,loss of appetite,red tongue,thin tongue fur,floating pulse,yellow tongue fur,sore throat,pulse slip,etc.;(2)The four methods of diagnosis information with high frequency of 121 cases of Qi phrase invisible stagnation heat syndrome is: red tongue,cough,low phlegm,fever,slip and rapid pulse,yellow fur,night sleep Insecure,etc.;(3)The four methods of diagnosis information with high frequency of 142 cases of phlegm stagnated heat syndrome is: cough,red tongue,fever,greasy yellow coating,yellow phlegm,loss of appetite,difficulty in sleeping,slippery pulse,phlegm and thick Fingerprint purple stagnation,etc.;(4)The four methods of diagnosis information with high frequency of 64 cases of muggy syndrome is: cough,less phlegm,thick tongue,red tongue,watery stools,greasy yellow coating,difficulty in sleeping,pulse slipping,low body heat,Runny nose,nasal congestion,fingerprint purple stagnation,vomiting,fever,etc.;(5)46 cases of dry stool stagnated heat syndrome with higher frequency of the four diagnosis information are: cough,no stool for 2 to 3 days,red tongue,thick phlegm,Constipation,fever,loss of appetite,yellow and greasy fur,slippery pulse,yellow fur,runny nose,stuffy nose,purple fingerprints,sleepless nights,etc.2.The secondary database of each syndrome type perform the data minning of association rule according to the parameter settings of support degree>10% and confidence degree>30%,and the calculation result showed that:(1)In the 83 cases of Wei phrase invisible stagnation heat syndrome,47 association rules were obtained when 83 items are associated with 2 health items;A total of 64 association rules were obtained when related to 3 items;a total of 25 association rules were obtained when related to 4 items.(2)In 121 cases of Qi phrase invisible stagnation heat syndrome,a total of 66 association rules were obtained when 2 items were associated;254 association rules were obtained when 3 items were associated;393 association rules were obtained when 4 items were associated;265 association rules were obtained when 5 items were associated A total of 60 records of association rules when associated with 6 items.(3)In the 142 cases of phlegm-heat stagnation syndrome,a total of 68 association rules were obtained when 2 items were associated;207 association rules were obtained when 3 items were associated;183 association rules were obtained when 4 items were associated;51 association rules were obtained when 5 items were associated.(4)In 64 cases of muggy syndrome,a total of 76 association rules were obtained when 2 items were associated;347 association rules were obtained when 3 items were associated;585 association rules were obtained when 4 items were associated;432 association rules were obtained when 5 items were associated.(5)In 46 cases of dry stool stagnated heat syndrome,a total of 112 association rules were obtained when 2 items were associated;553 association rules were obtained when 3 items were associated;1254 association rules were obtained when 4 items were associated;1416 association rules were obtained when 5 items were associated A total of 805 records of association rules are obtained when 6 items are associated;a total of 208 records are obtained when 7 items are associated;15 records are obtained when 8 items are associated.3.After screening the results of each classification,combined with the analysis of basic theories of traditional Chinese medicine and the theory of doctrine of epidemic febrile disease,the main symptom groups related to each syndrome type are:(1)The symptom groups related to Wei phrase invisible stagnation heat syndrome are: pulse slip,thin yellow fur,Pulse,cold wind,fever,nasal congestion,runny nose,low sputum,cough,sleeplessness,sore throat,loss of appetite,etc.,among them,there is a high probability of cooccurrence of fever and cough,co-occurrence of red tongue and thin coating,co-occurrence of cough Coexist with pulse float and pulse number,fever and thin fur coat and yellow fur.(2)The main symptom groups associated with Qifen invisible heat syndrome are: pulse slippage,fever,red tongue,sleepless night,phlegm,loss of appetite,cough,yellow fur,fingerprint purple stagnation,etc.,with a high probability of pulse Slip count and cough co-occurrence,fever and red tongue co-occurrence,night sleep insomnia,fingerprint purple stagnation and fur yellow co-occurrence.(3)The main symptom groups in phlegm-heat stagnation syndrome are: phlegm sticky cough,pulse slip,fever,red tongue,loss of appetite,sleepless nights,pale purple fingerprints,among which phlegm stickiness is difficult to occur and fever co-occurs,Yellow greasy fur and tongue red co-occurrence,fingerprint purple stagnation and tongue red co-occurrence,cough and sticky phlegm,and pulse slip co-occurrence.(4)The main symptom groups related to the syndrome of dampness and heat are: low body heat,short yellow urine,yellow greasy fur,slippery pulse,loose stools,vomiting,nasal congestion,runny nose,dizziness,purple fingerprint,which has a higher probability There are high probability of co-occurrence of short yellow urine and yellow greasy coating,co-occurrence of fingerprint purple stagnation and watery stools,co-occurrence of fingerprint purple stagnation and runny and thin yellow tongue fur.(5)The main symptom groups related to the syndrome of dry stools are: sleeplessness,fever,shortness of breath,constipation,no stools for 2 to 3 days,cough,pulse slip,phlegm,purple fingerprints,loss of appetite,etc.Among them,there is a high probability of co-occurrence of greasy yellow coating and tongue red,co-occurrence of pulse slippage and tongue red,co-occurrence of shortness of breath and stool constipation,cooccurrence of fingerprint purple stagnation and no stools in 2 to 3 days.Conclusion: 1.The syndrome differentiation method of stagnated heat syndrome is suitable for clinical syndrome differentiation of mycoplasma pneumonia in children,and can be used as one of its syndrome differentiation methods.2.Using the syndrome differentiation method of stagnated heat syndrome,mycoplasma pneumonia can be divided into: Wei phrase invisible stagnation heat syndrome,Qifen invisible stagnation heat syndrome,phlegm-heat stagnation syndrome,muggy syndrome,indigestion stagnation heat syndrome and dry stools stagnated heat syndrome.3.Based on clinical data,combined with association rules and other data mining methods,we can further summarize and standardize the syndrome differentiation method of febrile syndrome,and provide ideas for further innovation of syndrome differentiation of stagnated heat syndrome.