| Objective:The purpose of this study is to observe the clinical effect and adverse reactions of Xinwei Decoction in treating function al dyspepsia with insomnia(Disharmony of liver and stomach).Methods:Eighty functional dyspepsia patients with insomnia diagnose d as disharmony of liver and stomach were divided into treatme nt group and control group by random number table method.In the treatment group,40 patients were given xinwei decoction,a tra ditional Chinese medicine prescription,twice a day,for 30 min utes after meals.In the control group,40 cases were rationall y used according to different subtypes of FD.Pantopprazole ent eric-solution capsule was selected for patients once a day,ea ch time 40mg,and taken on an empty stomach in the morning.Or moxapitali citrate dispersible tablets three times a day,each time 5mg,30 minutes before the meal oral warm water,insomnia choose right zopicron tablets once a day,once 3mg,half anhour before bedtime oral;During the treatment,the patientswere f orbidden to take any drugs related to functional dyspepsiaor in somnia.Both groups of patients took the drugs continuouslyfor 4 weeks.During the treatment period,2 patients in the tre atment group were excluded because they failed to visit the doc tor on time to take medicine,while 3 patients in the control g roup were excluded because they were afraid of the side effects of drugs.In February,after the treatment,telephone follow-up observation records before and after treatment in patients with clinical symptoms,FD symptoms integral,Pittsburgh sleep scale(PSQI),will collect the data using SPSS 22.0 software analysis.~-x±s was used to represent the measurement data,t test measur ement data,chi-square test count data,rank and test classific ation data.P<0.05,statistically significant,P>0.05 said no statistical difference.Results:(1)During the treatment period,2 patients in the treatment group were excluded because they failed to visit the doctor on time to take medicine,and 3 patients in the control group were excluded because they stopped taking medicine by themselves.(2)Comparison of effective rates of EPS and PDS:there were4 cases in the treatment group with an effective rate of 75%,and 2 cases in the control group with an effective rate of 100%.The number of cases was too small to be statistically signific ant.There were 34 cases in the treatment group with an effecti ve rate of 91.18%,and 35 cases in the control group with an ef fective rate of 65.71%.(3)Comparison of FD effective rate:the effective rate of the treatment group was 89.47%and that of the control group wa s 67.57%,indicating that xinwei decoction was more effective t han western medicine groupin the treatment rate of functional i ndigestion.(4)Comparison of effective rate of insomnia:the effective rate of the treatment group was 92.11%and that of the control group was 94.59%,indicating that xinwei decoction had the sam e effect on the treatment rate of insomnia as the control group.(5)The FD symptoms integral,overall PSQI score integral c omparison:the two group after treatment FD symptoms integral,o verall PSQI scores integral difference compared with before tre atment,the treatment group and control group of FD symptoms ov erall integral change statistically significant(P<0.01),the tr eatment group and control group in PSQI score change no statis tical difference(P>0.05).(6)Comparison of TCM clinical symptoms of functional dyspe psia:compared with the control group,the treatment group signi ficantly improved the symptoms of abdominal distension,reflux heartburn,dry mouth and bitter mouth,and poor appetite(P<0.05).Both the treatment group and the control group could improve the symptoms of stomachache,early satiety,belching and nause a,but no statistical difference(P>0.05).(7)Comparison of TCM clinical symptoms of insomnia:compare d with the control group,the treatment group was more effectiv e in the improvement of symptoms of polysomnia,irritability an d light wakefulness(P<0.01).In terms of the improvement of di fficulty in falling asleep and early awakening symptoms,both t he treatment group and the control group improved significantly,but no significant difference(P>0.05).(8)During the treatment period,there was 1 case of mild d iarrhea in the treatment group and 3 cases of dizziness in the control group.Conclusion:The clinical test results show that the traditional Chinese medicine prescription hin stomach soup has obvious advantages,compared with western medicine can significantly reduce the cl inical symptoms of patients with functional dyspepsia with inso mnia,especially for abdominal distention,anti acid heartburn,dry mouth,mouth pain,poor appetite,upset,sleep easy to wak e,much dream wait for a symptom,is worth further research and extension. |
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