Evaluation Value Of PDW Combined With Coagulation Function In Chemotherapy Effect And Prognosis Of Lung Cancer Patients

Objective:To evaluate the significance of platelet distribution width and clotting function in lung cancer patients in predicting the curative effect and prognosis of chemotherapy.Methods:A retrospective analysis of basic information and clinical data of 168 patients with lung cancer admitted for initial diagnosis through pathology confirmed by the Rocky Mountain Hospital of Wannan Medical College from October 2017 to October2019,such as gender,age,smoking history,clinical stage,and type.Record the changes in serum platelet distribution width(PDW)and coagulation function indexes and efficacy at the first diagnosis and after two cycles of platinum-containing two-agent chemotherapy.According to the efficacy evaluation standard for solid tumors(RECIST1.1),evaluate different types of lung cancer after two cycles of chemotherapy The patient’s disease control rate was used as the curative effect.The patients were followed up and the overall survival(OS)of the patients was recorded in weeks.Statistical analysis was performed using SPSS25.0.The paired t test was used to compare the differences between PDW,PT,APTT,INR,FIB,and DD before and after 2 cycles of chemotherapy;COX regression was used to analyze their survival.Firstly,univariate COX was performed,and then univariate COX regression was statistically significant.Significant variables were brought into the multi-factor COX regression model to explore independent influencing factors affecting prognosis.Combine the ROC curve tounderstand its value for prognostic evaluation and determine the best cutoff value.The study set the test level a = 0.05,P <0.05 considered that the difference was statistically significant.By studying the changes of PDW and coagulation-related indexes in patients with lung cancer before and after chemotherapy,the relationship between chemotherapy efficacy and coagulation function is analyzed;the multivariate analysis of the prognostic factors of lung cancer patients is performed to analyze the platelet distribution width and coagulation index Relationship with the prognosis of patients with lung cancer.Results:After chemotherapy,patients with lung cancer have decreased PDW,PT,INR,FIB,DD,and elevated PT.Among these patients,the plasma D-dimer and fibrinogen values of those who responded decreased,while those who did not respond did not change significantly;it can be observed APTT increased in the ineffective patients,but no significant change in the effective group.The univariate survival analysis revealed that the abnormal changes in platelet distribution width and PT in the non-small cell lung cancer group affect the prognosis of patients,and both are independent factors that affect the prognosis;patients with abnormally elevated PDW,FIB,and DD in small cell lung cancer survive.Time is shortened.PT extension is most valuable in prognostic judgment of patients with lung cancer.Conclusion:Lung cancer patients are often accompanied by abnormal activation of the coagulation system,and the process of chemotherapy also affects the changes of the coagulation system,leading to changes in relevant indicators.Among all the factors,PDW,FIB and d-d may be the factors affecting the prognosis of patients with lung cancer,among which PDW and PT may be the independent prognostic factors affecting patients with non-small cell lung cancer,and PT,FIB and d-d are the independent prognostic factors affecting patients with small cell lung cancer.