| Objectives:To understand current situation and epidemic features of HBV among residents in Hu Bei province,as well as the inoculation status of Hepatitis B vaccines in different groups of people in Hu Bei;To evaluate the effect of implementation of Hepatitis B vaccines adding to the children’s immunization program,so as to provide scientific basis to make measures to prevent Hepatitis B more effecttively.Methods: The information of hepatitis B patients that reported from 2012 to 2016 in Hu Bei province was collected from the Epidemic Data Compilation and Chinese Disease Monitoring and Reporting System,and the data was analyzed with descriptive epidemiological method,which included different age,time,gender,occupation,etc.A multi-stage stratified random sampling method was conducted in 2016.Four prefectural-level cities were selected from Hu Bei province,and 24 villages or communities were randomly selected,and all the people can be divided into 10 age group,(0-year old group,the1-year old group,3-years old,5-years old group,7-,15-,20-,25-years old groups.)Each age group need to investigate 20 people(male 10,female 10).All the selected individuals were surveyed and collected peripheral blood on site.Hepatitis B virus surface antigen and hepatitis B virus surface antibody were tested in laboratory.All questionnaires were recorded by double entry method in Epidata3.1,the data was analyzed by Excel 2007 and SPSS 17 software,and the comparison between different rates was analyzed by chi square test,trend chi square test and Fisher exact probability method.Results:(1)The epidemic characteristics of hepatitis B in Hu Bei province:There were 305,879 reported cases of hepatitis B in Hu Bei province from 2012 to 2016.The average annual reported incidence rate was 105.46 per 100000 people,and the highest year of reported incidence rate(109.86 per 100,000)was in 2012,while the lowest(100.32 per100,000)was in 2014,and the difference of incidence of each year was not significant.The number of reported hepatitis B cases has long been ranked the first in the category B infectious disease reporting system in Hu Bei.(2)Inoculation of hepatitis B vaccines: The average hepatitis B vaccine inoculation rate of the Suzhou citizens is 74.47%.The highest hepatitis B vaccine inoculation rate was 1-year old group(94.53%),while the lowest was 25-years old group(30.60%)in different age group;The highest hepatitis B vaccine inoculation rate was preschool children group(90.31%),while the lowest was worker group(20.51%)in different occupation group;The hepatitis B vaccine inoculation rate of people that born after 2003(90.42%)was higher than that born before 2003 。 group(48.32%);The difference of hepatitis B vaccine inoculation rate was significant between different age、occupation、arear group.(3)The positive rate of people’s hepatitis B virus surface antigen and hepatitis B virus surface antibody was 2.49%(95/3816)、 72.41%(2763/3816).The highest positive rate of people’s hepatitis B virus surface antigen was Wu Han(3.23%),while the lowest was Sui Zhou(1.71%)in different arear,the highest positive rate of people’s hepatitis B virus surface antigen was 20-years old group(4.84%),while the lowest was 1-year old group(1.01%)in different age group,the positive rate of people’s hepatitis B virus surface antigen of people born after 2003(1.60%)was lower than than born before 2003(3.94%);the positive rate of people’s hepatitis B virus surface antigen of people that vaccinated(2.04%)was lower than that not vaccinated(3.80%).The difference of hepatitis B vaccine inoculation rate was significant between different age、occupation、and history of inoculation group.The highest positive rate of people’s hepatitis B virus surface antibody was Xian Ning(79.69%),while the lowest was Sui Zhou(66.06%)in different arear,the highest positive rate of people’s hepatitis B virus surface antibody was 0-years old group(99.65%),while the lowest was 25-year old group(59.75%)in different age group,the positive rate of people’s hepatitis B virus surface antibody of people born after 2003(73.50%)was lower than than born before 2003(69.36%);the highest positive rate of people’s hepatitis B virus surface antibody was preschool group(77.01%),while the lowest was leader group(52.94%).The difference of hepatitis B vaccine inoculation rate was significant between different age、occupation、and arear group.Conclusion: The reported incidence of hepatitis B in Hu Bei still kept a high level in 2012-2016,the reported cases mainly occurred in people>15 years old,and the main occupation of the reported cases was farmer.(2)Hu Bei has significantly improved the hepatitis B vaccine inoculation rate and reduced the HBs Ag incidence rate by fully implementating the plan that adding the Hepatitis B vaccines to the children’s immunization program in 2003.(3)the HBs Ag Positive Rate among children above 15 years was in a relative high level while the HBs Ab Positive Rate among children above 15 years was relatively low,as well as the farmer group.We should strengthen the implementation in the older people and farmer in the immunization program. |
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