Clinical Study Of Gancao Xiexin Decoction In The Treatment Of Chemotherapy-related Oral Ulcers

Objective: To observe the clinical efficacy and safety of Gancao Xiexin Decoction in the treatment of chemotherapy-related oral ulcers.Methods: According to the principle of random control,64 patients with chemotherapy-related oral ulcers were divided into two groups,32 in the treatment group and 32 in the control group.During the study,due to irregular medication,non-compliance with the test,and voluntary termination of the test,etc.,The treatment group and the control each lost one case,and the final number of effective cases in each group was 31 cases.The treatment group was given oral administration of traditional Chinese medicine decoction Gancaoxiexin decoction,and the control group was given topical external treatment with recombinant bovine basic fibroblast growth factor for 10 days.During the observation period,the two groups used the same conventional symptomatic supportive treatment,and the nursing level of the two groups was roughly the same.Statistical analysis of changes in the indexes of oral ulcer grading,pain,ulcer duration,number of ulcers,ulcer diameter,serum IL-2 level,TCM syndrome score before and after treatment in the two groups of patients,and detailed records of the treatment period of the two groups Security indicators.Results:(1)Efficacy evaluation:(1)oral ulcer classification: the comparison of oral ulcer classification between the two groups after treatment,the difference between the groups was not significant(P>0.05);(2)oral ulcer pain assessment: the oral ulcer pain score of both groups was reduced after treatment,And the effect of the treatment group was better than that of the control group(P<0.05);(3)ulcer duration: the average ulcer duration between the two groups after treatment was not significantly different between the groups(P>0.05);(4)ulcer diameter: after treatment,the ulcer diameter was reduced,And the effect of the treatment group was better than the control group(P<0.05)(5)Number of ulcers: After treatment,the number of ulcers in both groups decreased,and the effect of the treatment group was better than the control group(P<0.05)(6)Serum IL-2 level: treatment The serum IL-2 levels of the latter two groups increased,and the effect of the treatment group was better than that of thecontrol group(P<0.05)(7)TCM syndrome score: total effective rate of the treatment group: 87.09%,total effective rate of the control group: 74.19%,group The difference between the two groups was not significant(P>0.05);(8)Quality of life: The KPS scores of the two groups were improved after treatment,the treatment group was better than the control group,and the difference between the groups was statistically significant(P<0.05).(2)Safety assessment: The occurrence of adverse reactions in the two groups was mainly mild abnormalities in myocardial enzymes,electrocardiogram,and stool routine.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:1.Gancaoxiexin Decoction can be used to treat chemotherapy-related oral ulcers,its efficacy is roughly the same as that of Western medicine recombinant bovine basic fibroblast growth factor,but in reducing the pain of ulcers,reducing the diameter of ulcers,reducing the number of ulcers,serum IL-2 level is superior to recombinant bovine basic fibroblast growth factor;2.The incidence of adverse reactions during the study is low,and there is no significant difference between the two groups,Gancaoxiexin decoction is safe and effective;3.Gancaoxiexin decoction is in In this study,the effect is good,the price is low,and it is convenient to take,which is worthy of further clinical research.