| OBJECTIVE:Chronic heart failure is the last stage of many cardiovascular diseases,and its treatment has been a major problem in the medical field.According to the theory of Mongolian medicine,this study applied Mongolian medicine pulse cathartic The effects of NT-pro BNP,LVEF,New York heart function classification,6 minute walk test,Minnesota heart failure quality of life scale,Mongolian medicine syndrome score and readmission rate were observed in the randomized and controlled clinical validity and safety,and then for the treatment of chronic heart failure patients,improve clinical efficacy,for the treatment of chronic heart failure to expand new areas.METHOD:60 patients who met the inclusion criteria were randomly divided into observation group and control group,30 in each group.The control group was treated with conventional western medicine for chronic heart failure(ACEI or ARB,?-blocker and aldosterone blocker).The observation group was treated with Ganlu Yangxin pill twice a day,15 capsules a time,42 days as a course,84 days in total.The influence or change rate of NT-pro BNP,left ventricular ejection fraction,New York Heart function classification,6-minute walking test,Minnesota Heart Failure Quality of life scale,Mongolian medicine syndrome score scale were observed in 42 days and 84 days after treatment,and compared with those before treatment and between groups.The readmission rate of the two groups within 1 month after treatment was observed Row group comparison.The data were analyzed by SPSS 23.RESULT:After 42 days of treatment,the NT-pro BNP level in the two groups decreased significantly(P < 0.05)compared with that before treatment,and the level in the observation group decreased more significantly(P < 0.05).After 84 days of treatment,the NT-pro BNP level of the two groups decreased significantly(P < 0.05)compared with that of the observation group(P < 0.05).After 84 days of treatment,the effective rate of NT-pro BNP decreased by 30% in the observation group was 86.6% and 67.3% in the control group,with significant difference between the two groups(P < 0.05).After 84 days of treatment,the left ventricular ejection fraction of the two groups was significantly improved(P < 0.05),and there was no significant difference between the two groups(P > 0.05).After 84 days of treatment,the total effective rate of the New York Heart function grading observation group was 93.3%,and that of the control group was 76.6%.There was a significant difference between the two groups(P < 0.05).After 84 days of treatment,the 6-minute walking distance and Minnesota Heart Failure Quality of life scores of the two groups were significantly improved(P < 0.05),and there was a significant difference between the two groups(P < 0.05).After 84 days of treatment,the total effective rate of the observation group was 86.7% and that of the control group was 73.3%.There was a significant difference between the two groups(P < 0.05).Within 30 days after 84 days of treatment,the rehospitalization rate was 6.7% in the observation group and 10% in the control group.There was no statistical difference between the two groups(P > 0.05).During the treatment,the blood and urine routine,liver(AST,ALT),kidney(Cr,BUN)function and electrolyte were not found to have obvious abnormal changes.CONCLUSIO:The application of guiganlu Yangxin pill combined with western medicine in the treatment of chronic heart failure can significantly reduce the level of NT pro BNP,improve the symptoms and quality of life of heart failure,significantly improve exercise tolerance,and have no adverse reactions.It can be a new way for Mongolian medicine to treat chronic heart failure. |
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