Clinical Observation Of Liuwei Dihuang Pill Combined With Fenmotong In The Treatment Of Decreased Ovarian Reserve Function With Kidney-yin Deficiency

Objective:To observe the clinical efficacy of Liuwei Dihuang Pills combined with Fenmatol in the treatment of kidney-yin deficiency-type ovarian reserve decline and changes in related medical indicators,and objectively evaluate the efficacy.Methods:Sixty-six patients with kidney yin deficiency type ovarian reserve decreased in the infertility department,obstetrics and gynecology department and inpatient department of Gansu Provincial Hospital of Traditional Chinese Medicine from December 2019 to December 2020 were included in the experiment,and they were randomly divided into treatment groups,In the control group,there were 33 cases in each group.Treatment group:Liuwei Dihuang Pills combined with Fenmatol treatment,control group:Fenmatol treatment,after 3 courses of treatment,observe the general items of the two groups of patients before and after treatment（age,age at menarche,time of onset,history of pregnancy and childbirth,etc.）,Clinical symptom observation index（Chinese medicine symptom score table）,hormone level determination（E₂,FSH,LH,AMH）,vaginal ultrasonography（bilateral ovarian size, number of antral follicles）,safety observation index,and evaluation of Liuwei Dihuang Pills The curative effect is evaluated objectively.Results:1.Before treatment,the age,age at menarche,course of disease,pregnancy history,TCM syndrome score before treatment,serum FSH,LH,FSH/LH,E₂,AMH value,bilateral ovarian volume and antral follicles of the treatment group and the control group before treatment Compared with the numbers,the difference is not statistically significant（P>0.05）,indicating that the two groups are comparable,and this study can be carried out.2.Comparing the efficacy of TCM syndromes between the two groups after treatment,the effective rate of the treatment group was 90.32%;the effective rate of the control group was 68.75%;after the rank sum test,Z=2.343,P=0.019<0.05,the difference was statistically significant.It shows that the therapeutic effect of the treatment group on the TCM syndromes of kidney yin deficiency type DOR is better than that of the control group.3.After treatment,the total scores of TCM syndromes of the two groups of patients were lower than before treatment,and the differences between the comparisons within and between the groups were statistically significant（P<0.05）,indicating that both groups can improve the TCM of patients with kidney-yin deficiency type DOR Syndrome score,but compared with the control group,the treatment group has more prominent curative effects.4.After treatment,the single TCM syndrome scores were compared,the treatment group and the control group were both lower than before treatment,and the difference was statistically significant（P<0.05）.After treatment,the single TCM syndrome scores of the two groups were compared,except for menstrual cycle and bone.There was no statistically significant difference in the scores of steaming hot flashes and hand-foot-heart heat（P>0.05）,and the scores of other syndromes were statistically significant（P<0.05）,indicating that the treatment group is improving the single TCM syndrome of DOR patients Except for menstrual cycle,bone steaming and hot flashes,hand,foot and heart heat,the scores were better than those of the control group.5.Comparing the serum indexes of the two groups of patients,the AMH and E₂values of the treatment group and the control group after treatment were higher than before treatment,and the FSH and FSH/LH values were lower than before,the difference was statistically significant（P<0.05）,The LH value did not change significantly,and the difference was not statistically significant（P>0.05）;the comparison between the groups,except for the LH value,the difference was statistically significant（P<0.05）,indicating that the treatment group was able to improve the serum index of DOR patients.The control group is good.6.Comparing the bilateral ovarian volume and the number of antral follicles between the two groups of patients,the bilateral ovarian volume of the treatment group and the control group were both larger than before treatment,and the number of antral follicles increased compared with before treatment.The difference was statistically significant（P<0.05）After treatment,the comparison of bilateral ovarian volume and number of antral follicles between the two groups of patients was statistically significant（P<0.05）,indicating that the treatment group was better than the control group in improving the bilateral ovarian volume and the number of antral follicles.7.Comparison of long-term curative effect,the exacerbation rate of clinical symptoms after drug withdrawal of the treatment group and the control group were 6.45%and 28.13%respectively,the difference was statistically significant（P<0.05）,indicating that the long-term curative effect of the treatment group was better than that of the control group.Conclusion:1.Liuwei Dihuang Pill combined with Fenmalong can improve the TCM syndromes of DOR patients with kidney-yin deficiency,reduce the TCM syndrome score,and the total effective rate is higher than that of the control group using Fenmalong alone.2..Liuwei Dihuang Pills combined with Fenmatong in the treatment of kidney-yin deficiency DOR can improve ovarian function in terms of adjusting the patient’s hormone levels,increasing transforming growth factors,increasing bilateral ovarian bodies and increasing the number of antral follicles,and the effect is better than simply using Fen.Matong’s control group.