Analysis Of Factors Affecting Secondary Damage In Acromegaly

ObjectiveThe purpose of this study was to explore the effects of growth hormone and other possible related factors on secondary damage of acromegaly including heart damage,hypertension and abnormal glucose metabolism.Methods50 cases of acromegaly in the Department of Neurosurgery and Endocrine Department of General Hospital of Ningxia Medical University and Cardiovascular and Cerebrovascular Disease Hospital were collected and analyzed retrospectively to explore the effects of age,sex,course of disease,random growth hormone level,OGTT test GH valley value and cumulative effect of growth hormone on secondary heart damage,hypertension and abnormal glucose metabolism in acromegaly.ResultsAmong the 50 cases,29(57.9%)were male,21(42.1%)were female,26(52%)had normal heart,24(48%)had heart damage,including 13(26%)with enlarged left atrium,12(24%)with enlarged left ventricular diameter and 7(14%)with thickened left ventricular wall or interventricular septum.So all cases were divided into heart damage group and normal heart group.There were 16 cases(32%)with abnormal glucose metabolism and 34 cases(68%)with normal glucose metabolism.All cases were divided into normal glucose metabolism group and abnormal glucose metabolism group.There were 13 cases(26%)with hypertension and 37 cases(74%)with normal blood pressure.All cases were divided into hypertension group and non-hypertension group.The influencing factors of the above three cases were analyzed.The results showed that the proportion of hypertension in the myocardial damage group was higher than that in the normal group,and the),BMI index was positively correlated with the left ventricular diameter(P<0.05).Among other factors,the course of disease,age and the cumulative effect of growth hormone in the heart damage group were higher than those in the normal group,but the difference was not statistically significant.The age in hypertension group was significantly higher than that in non-hypertension group,and the difference was statistically significant(P<0.006).The proportion of heart damage in hypertension group was significantly higher than that in non-hypertension group(P<0.05).Among other factors,the proportion of abnormal glucose metabolism and family history of hypertension was significantly higher than that in non-hypertension group,but the difference was statistically significant.The course of disease,random growth hormone level and cumulative effect of growth hormone in hypertension group were higher than those in non-hypertension group,but the difference was not statistically significant.In the abnormal glucose metabolism group,the random growth hormone book review and the cumulative effect of growth hormone were significantly higher than those in the normal group,and the difference in random growth hormone level was statistically significant(P<0.005),and the difference in the cumulative effect of growth hormone was also statistically significant(P< 0.025).Among other factors,the age,course of disease,OGTT test GH valley value and BMI index in the abnormal glucose metabolism group were higher than those in the normal glucose metabolism group.However,there was no statistical significance.The proportion of dyslipidemia in the abnormal glucose metabolism group was significantly higher than that in the normal glucose metabolism group,but the difference was not statistically significant(P>0.05).ConclusionHypertension secondary to acromegaly and cardiac damage influence each other in the course of disease progression;In the process of cardiac damage secondary to acromegaly,the left ventricular diameter was positively correlated with BMI,age was an important influencing factor of hypertension secondary to acromegaly,and random growth hormone level and cumulative effect of growth hormone were important influencing factors of glucose metabolism abnormalities associated with acromegaly.Further understanding of the secondary damage of acromegaly,early diagnosis,early clinical intervention,and reducing the hormone level of acromegaly patients are of great significance for improving the quality of life,improving the long-term prognosis and reducing the mortality of patients.