Clinical Observation On Treatment Of Damp-heat Blocking Collaterals Type Osteoarthritis Of Knee Joint By Improvement Shuangbai Powder

Objective: The aim of this study was to investigate the clinical efficacy of Shuangbai powder in the treatment of knee osteoarthritis with damp-heat blocking collaterals.By comparing the improvement of TCM syndrome score,pain,swelling,Local skin temperature,joint motion,and related inflammatory factors before and after treatment.Preliminary analysis of the possible mechanism of modified Shuangbai San treatment of this disease,For the treatment of damp-heat blocking collaterals type knee osteoarthritis to find a new legislative direction,and then improve the clinical treatment effect of this disease.Method: This study uses the random number table method,Patients with osteoarthritis of the knee who met the inclusion criteria were divided into control group and treatment group,each group of 40 cases.The control group was treated with non-drug therapy(Bed rest,Appropriate training of muscle strength around the knee,etc.)combined with ibuprofen sustained-release capsule.The treatment group was treated in the control group,With the improved double cypress powder,Once a day,time about2 hours.Both groups had nine days of treatment.The degree of swelling of the knee after treatment,local skin temperature of knee joint,TCM syndrome score,VAS score,WOMAC score,clinical efficacy,and TCM syndrome efficacy were compared.At the same time,the safety indicators were observed and recorded.All the data obtained in this study are analyzed by data analysis software SPSS21.0.Results: Before treatment,compared with the control group,there was no significant difference in sex,age,course,Kellgren-Lawrence grade andswelling degree grade between the two groups(all P>0.05).After treatment,the swelling degree of knee joint in both groups was lower than before treatment(P<0.05),and the treatment group was significantly better than the control group(P<0.01);Both groups had significant difference in local skin temperature(P<0.05),and the treatment group was significantly better than the control group(P<0.01);The results of the two groups showed that,the total effective rate in the control group was about 71%,the total efficiency of the treatment group was about 92%,clinical efficacy of the treatment group was significantly better than that of the control group(P<0.01);Both groups had statistical difference in TCM syndromes score compared with those before treatment(P<0.05),and the treatment group was better than the control group(P<0.05);The results of TCM syndromes in both groups showed that,the total efficiency of the control group was about 76%,the total efficiency of the treatment group was about 92%,effect of TCM syndrome in treatment group was better than that in control group(P<0.05);The VAS scores of knee joint in both groups were statistically different(P<0.05),and the treatment group compared with the control group VAS score,no statistical differences(P>0.05);The WOMAC scores of knee joint in both groups were statistically different(P<0.05),and the scores of the treatment group were significantly better than those of the control group(P<0.01);The CRP and ESR values of the two groups were statistically different(P<0.05),and the treatment group was significantly better than the control group(P<0.01).Conclusion: Modified Shuangbai powder external application combined with ibuprofen sustained release capsule in the treatment of damp-heat blocking collaterals type knee osteoarthritis,It is better to use ibuprofen sustained release capsule alone,after treatment,the treatment group improved joint inflammation,reduced joint swelling,reduced local skin temperature,relieved pain and recovered joint function better than the control group.