Clinical Effect Observation Of Sishen Decoction Combined With Simiao Powder In Treatment Of Knee Osteoarthropathy Synovitis (Wet Injection Joint Type)

Objective:This paper through the design of Clinical Randomized Controlled Trials,observing Sishen Decoction and Simiao Decoction to add and subtract,inflammatory synovitis of knee joint syndrome is a wet type joint of the patient’s clinical curative effect,with oral Chinese Medicine Treatment group and oral synovitis granules curative effect comparison between the positive control group,the objective evaluation of the Sishen Decoction and Simiao Decoction for the treatment of patients with knee joint inflammatory synovitis.Relevant data collected from clinical observation reflect the therapeutic effect of Professor Wang Xuan on wet injection joint synovitis of knee and bone by adding and subtracting Sishen Decoction and Simiao Decoction.At the same time,it is proved that the early intervention and treatment of synovitis can better improve and prevent the symptoms and improve the quality of life of patients with Knee Osteoarthritis,and provide scientific basis and enrich the theory of treatment for the conservative treatment of patients with Knee Osteoarthritis.Methods:Patients with Knee Osteoarthritis Synovitis who visited the inpatient department and outpatient department of The Hospital of Shanxi University of TCM from November 2018 to December 2020 were collected.SAS9.1 software was used to generate random numbers by computer software.The treatment group was odd number,and the control group was oppositely.Simiao Decoction Granules(Guangdong Yifang Granule Company,Affiliated Hospital of Shanxi University of TCM)orally twice a day.The control group was given synovitis granules(Shenwei Pharmaceutical(Zhangjiakou)Co.,LTD.)orally three times a day for one week,for a total of 4 weeks.VAS score,swelling degree,WOMAC score,TCM syndrome score,adverse reactions,etc.were collected during the process of treatment in the two groups,and SPSS26.0 was used for statistical analysis and efficacy evaluation of the data.Results:In this research,there were total 60 subjects were involved and there were no shedding cases.All subjects completed the treatment course.All cases were statistically analyzed,and the results were as follows:1.Baseline conditions of the two groups before treatment,such as age,gender,BMI,degree of swelling,VAS score,WOMAC score and TCM syndrome score were statistically contrasted,there was no statistical significance in differernce(P>0.05),illustrating that the data between the therapeutic group and the control group were comparable before the research.2.7 days after treatment,the pain score showed no obviously significant difference in two groups(P>0.05).It shows significant differences in WOMAC score,such as stiffness degree,difficulty in daily activities and syndrome score of TCM(P < 0.05).Before and after treatment,the difference between the two groups were no significantly(P < 0.05).It was suggested that both treatment methods were effective.In terms of short-term efficacy,the therapeutic effects of the two groups were comparable.3.Two weeks after treatment,there was no difference between the two groups in VAS score statistically significant(P>0.05);the differences in WOMAC total score and scores of each item(pain degree,stiffness degree and difficulty in daily activities)and TCM syndrome score(P <0.05)were significant.Before and after treatment,the two groups also showed that the difference was in statistically significant(P <0.05).4.Four weeks after treatment,It shows significant differences in scores of VAS,WOMAC,TCM syndrome and swelling degree between the two groups;At the same time,the difference before and after treatment was also significant(P < 0.05).It indicated that both groups could effectively improve the symptoms of patients with knee osteoarthritis synovitis after treatment,the treatment group was better in the curative effect than that of the control,especially the long-term curative effect,the treatment group had obvious advantages.5.Efficacy evaluation between the two groups: after treatment,there were 30 cases in the treatment group,3 cases in clinical control,15 cases show curative effect,10 cases were effective and 2 cases were ineffective.It show 93.3% effective rate totally in treatment group;In the control group,there were 30 cases,1 case in clinical effect,8 cases show curative effect,16 cases of effective,5 cases of invalid,with a total effective rate of83.3%.After statistical comparison of the overall therapeutic effect between the two groups,no significant difference was found(P > 0.05),that is,the therapeutic effect of the two groups was similar.There was no statistical significance in the ADR of the two groups during the treatment(P > 0.05).Conclusion:Sishen Decoction and Simiao Decoction has an effect on knee joint inflammation synovitis(wet injection joint syndrome),which is comparable to the control group of synovitis granule in terms of short-term effect.Both of them can effectively reduce patients’ pain,swelling and TCM syndromes,but the long-term effect is obviously better than the control group.Professor Wang Xuan differentiated Synovitis of Knee Osteoarthritis clinically,not only from the external perception of wind,cold,dampness,obstruction of muscles and collaterals,but also from the long-standing disease from blood stasis and lingering disease.Its syndrome differentiation is flexible,and the teacher inherited and innovated from the ancient times,using prescription,guard is dispelled evil to eliminate pathogenic factors,and taking defensive medicine.The addition and reduction of Sishen Decoction and Simiao Decoction can effectively improve the symptoms of patients with Knee Osteoarthritis synovitis,and from the perspective of treating the undisease,it can better prevent and improve the quality of life and clinical symptoms of KOA patients,with fewer untoward effect,which is worthy of application and further clinical promotion.