Observation Of Clinical Efficacy Of An Nao Fang In Treating Children’s Tic Disorder(Yin Deficiency And Yang Hyperactivity)

Objective: To evaluate the effectiveness and safety of Professor Wang Lie’s self-made "An Nao Fang" for children with tic disorder(yin deficiency and yang hyperactivity),and to analyze the academic thought and clinical experience of Professor Wang Lie in the field of treating children suffering from tic disorder.Methods: In this study,the before-and-after controlled trial method was adopted,and the total sample included 72 cases.The enrolled subjects were all treated with An Nao Fang for 3 months continuously.In 3 different days before and after the treatment,namely short course treatment: 30±3 days,medium course treatment: 60±3 days,and long course treatment: 90±3 days,researchers evaluated and recorded subjects’ vocal tic score,motor tic score,YGTSS total score,Traditional Chinese Medicine(TCM)syndrome score and adverse events.Variance analysis was repeated to calculate the decline of YGTSS and TCM syndrome scores in short course,medium course,and long course of treatment.In addition,the total clinical effective rate of 3 different observations was calculated for the evaluation of the effectiveness and safety of "An Nao Fang".Results: 1.The score of vocal tics before and after treatment displayed significant differences(F=154.061,P=0.000),with obvious linear decrease trend(F=199.445,P=0.000),and the differences among different observations were statistical significance(P<0.01).2.The score of motor tics before and after treatment had significant differences(F=374.222,P=0.000),with significant linear decrease trend(F=604.185,P=0.000),and the differences among different observations were statistical academic significance(P<0.01).3.The total score of YGTSS before and after treatment illustrated significant differences(F=353.267,P=0.000),with significant linear decrease trend(F=489.528,P=0.000),and the differences among different observations were statistically significant(P<0.01).4.The TCM syndrome score before and after treatment demonstrated significant differences(F=357.955,P=0.000),with significant linear decrease trend(F=555.173,P=0.000),and the differences among different observations were statistical significance academically(P<0.01).5.With YGTSS score as the evaluation standard,the total clinical effective rates of short,medium and long course of treatment were 73.53%,80.88%,and 89.71%,respectively.The total effective rate of medium course treatment was higher than that of short course,and the differences were not statistically significant(P>0.05).The total effective rate of long course treatment was higher than that of short course treatment,and the differences were statistically significant(P<0.05).6.Based on the evaluation criteria of TCM syndrome scores,the total clinical effective rates of short,medium and long course of treatment were70.59%,75.00%,and 88.24%,respectively.The total effective rate of middle course treatment was higher than that of short course,and the differences were not statistically significant(P>0.05).The total effective rate of long course treatment was higher than that of short course treatment,and the differences were statistically significant(P<0.05).7.Intervention drugs are safe.Conclusion: 1.Professor Wang Lie believes that kidney deficiency and excessive heart and liver are important to the pathogenesis of children’s tic disorder.The clinical treatment by calming the liver,calming the nerves,invigorating the kidney and invigorating the brain.2.An Nao Fang is safe and effective in treating tic disorder of Yin deficiency and Yang hyperactivity,and the clinical efficacy is positively correlated with the duration of intervention.