| Objectives:Based on the correlation between nutritional short stature(spleen and stomach deficiency syndrome)and intestinal flora imbalance,the traditional Chinese medicine "growth powder" was used to treat nutritional short stature(spleen and stomach deficiency syndrome).The changes of intestinal flora types,abundance and clinical efficacy were observed.It was confirmed that the traditional Chinese medicine "growth powder" could regulate the intestinal flora in the treatment of short stature,so as to provide a new direction for traditional Chinese medicine treatment of short stature.Methods:103 children with nutritional short stature(spleen and stomach deficiency syndrome)were randomly divided into treatment group(50 cases)and control group(53cases).The treatment group was treated with traditional Chinese medicine "growth powder" orally,and the control group was treated with compound Lactobacillus acidophilus tablets orally.One month was a course of treatment,up to three courses of treatment.One month after treatment,diet,exercise,sleep and eating habits were recorded.Intestinal flora was reexamined after one and two months of treatment.Height and weight were reexamined after three and six months of treatment.Bone age was reexamined after 6 months of treatment.All clinical data were statistically analyzed.Results:1.Among the 103 children included in this study,7 were detached halfway,47 were in the treatment group with complete data for statistical study,49 were in the control group,and before treatment,the average age and gender composition as well as general data such as height,weight,bone age,dietary habits and symptoms were compared between the two groups,with no significant differences(P > 0.05).2.A total of 84.38% of the children underwent GI ultrasonography,and among them,33.33% had gastrointestinal diseases such as chronic gastritis,which was not statistically different between the two groups(P > 0.05).The corresponding combination of traditional Chinese and Western medicine was performed on children who were examined to have gastrointestinal diseases,and gastrointestinal color ultrasound was reviewed 6 months later,showing recovery in both groups.3.Score of eating habits and symptoms: the scores of the two groups were significantly different before and after treatment(P < 0.05),the scores of the two groups were significantly different after treatment(P < 0.05),and the scores of eating habits and symptoms of the treatment group were better than those of the control group.4.Intestinal flora: the percentage of each major phylum in intestinal flora before treatment showed no significant difference between the two groups(P > 0.05).The levels of Firmicutes and Bacteroidetes were significantly different before and after treatment(P < 0.05)in the treated group and in the control group after 1 month and 2 months,respectively,and the levels of Firmicutes and Bacteroidetes were significantly different between the two groups after treatment(P < 0.05),indicating that both groups could improve the proportion of Firmicutes and Bacteroidetes in the intestine,which was better in the treated group than in the control group before and after treatment in the Proteobacteria treated group after 1month The difference between the treatment groups was statistically significant(P < 0.05),that of the control group was not significant(P > 0.05),that of the comparison between the two groups and that of the pretreatment group after 2 months of treatment was significant(P< 0.05),that of the treatment group was able to modulate the proportion of the phylum Firmicutes in the intestine,that of the treatment group was better than that of the control group,that of the comparison between the treatment group and the control group before and after the treatment of Fusobacterium The difference was statistically significant(P < 0.05)between the two groups after 1 month of treatment,and the difference was statistically significant(P < 0.05)between the groups after 2 months of treatment,indicating that both groups can regulate the Fusobacterium phylum content in the intestine to a similar extent at1 month of treatment,and the treatment group is superior to the control group at long-term efficacy.In terms of regulating intestinal Actinobacteria,there was no significant difference in the contrast of actinobacteria abundance before and after treatment between the two groups(P > 0.05),indicating that the proportion of Actinobacteria in intestinal flora was not significantly affected by the two methods.5.Bone age: after 6 months of treatment,all the pre-and post-treatment contrasts were statistically significant(P < 0.05),and there was no significant difference in the amount of bone age advancement between the two groups after treatment(P > 0.05).6.Height and weight: at 3 months after treatment,the height and weight of the treatment group were significantly different from those of the pretreatment group(P < 0.05),the weight of the control group was significantly different from that of the pretreatment group(P < 0.05),the height and weight of the control group were not different from those of the pretreatment group(P > 0.05),and at 6 months after treatment,the height and weight of the two groups were significantly different from those of the pretreatment group(P < 0.05)All were statistically significant(P < 0.05)better in the treatment group than in the control group.Conclusion:1.The treatment of nutritional short stature(spleen and stomach weakness syndrome)with Chinese medicine "" growth San "" and compound Lactobacillus acidophilus tablets improved dietary habits and symptom scores to a better degree than the control group,indicating that Chinese medicine " growth San " has better efficacy in improving children’s appetite,correcting anorexia,hemianorexia,and improving accumulation,abdominal pain,and stool disorders.2.Previous studies have demonstrated that children with nutritional short stature(spleen and stomach weak syndrome)have abnormal alterations in the abundance of the main phyla of intestinal flora,in which the percentage of Firmicutes and Proteobacteria is higher than that of normal children,and the percentage of Bacteroidetes and fusobacteria is lower than that of normal children.In this study,the percentage of Firmicutes,Bacteroidetes and Proteobacteria phyla in children tended to be normal after treatment in two groups of traditional Chinese medicine " growing San " and compound Lactobacillus acidophilus tablet,and the treatment group had better efficacy than the control group;Improvement in Fusobacterium the short-term outcome was not significant in either group,and after 2months,the efficacy of the treatment group was better than that of the control group.It is indicated that TCM " growth San " can regulate the proportion of the main phyla,such as Firmicutes and Proteobacteria in the intestine,and improve the state of intestinal flora Dysbiosis.3.Both " growth scatter " and compound Lactobacillus acidophilus tablet treatment for 6 months had the effect of improving height weight,and the effect of " growth scatter " was better than that of compound Lactobacillus acidophilus tablet. |
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