| Objective:This paper mainly takes patients with non-small cell lung cancer(NSCLC)as the research object,and observes the clinical effect on patients with advanced lung and spleen Qi deficiency type by using the same internal and external treatment of Du Meridian Moxibustion combined with Shenqi Fuzheng injection.To evaluate its role in relieving clinical symptoms of traditional Chinese medicine,regulating body immune function,reducing bone marrow suppression and improving quality of life,Explore the important position of traditional Chinese medicine in adjuvant chemotherapy,and provide new ideas for the prevention and treatment of tumors with traditional Chinese medicine.Methods:This study is an open-label randomized clinical trial.108 patients with advanced lung and spleen-qi deficiency NSCLC were divided into 3 groups based on chemotherapy.Group A used Du Meridian Moxibustion therapy,group B used Shenqi Fuzheng Injection,and group C used Du Meridian Moxibustion combined with Shenqi Fuzheng Injection,observed for 1 cycle,recorded the changes of TCM symptoms before and after treatment,lymphocyte subsets and white blood cell(WBC),hemoglobin(HB),platelet(PLT)indexes before and after treatment and on days 9 and 15 of treatment,KPS and changes in safety indicators,the obtained data were analyzed statistically.Results:A total of 105 patients completed clinical observations,of which 36 patients in group A completed all clinical observations,34 patients in group B completed clinical observations(2 patients fell off due to deterioration during treatment),and 35 patients in group C completed clinical observation(1 patient fell off due to poor compliance);1.TCM symptom evaluation:(1)Before treatment of each symptom:TCM symptom scores of the three groups are not statistically significant(p>0.05),indicating that they are comparable.(2)After the treatment of each symptom:there is no significant difference in the scores of cough,sputum and wheezing(p>0.05);in shortness of breath,spontaneous sweating,physical significant differences in fatigue scores,lack of appetite,abdominal distension,and abnormal stool scores(p<0.05);further pairwise comparison,in the scores of shortness of breath,spontaneous sweating,and fatigue,the difference between groups A and B was not significant(p>0.05),The difference between group C and group A and group B is significant(p<0.05);the difference between group A and group B is significant in the scores of lack of appetite,abdominal distension,and abnormal stool(p<0.05),group C was compared with group A and group B,of which the difference between group C and group A was significant(p<0.05),and there was no significant difference between group C and group B(p>0.05).(3)After treatment in each symptom group before and after treatment:there was no significant difference in cough and sputum scores among the three groups(p>0.05);there was no statistically significant difference in group A in terms of lack of appetite,abdominal distension,and abnormal stool(p>0.05);the remaining treatment points have significant differences(p<0.05).(4)Total scores before and after treatment:There is no statistically significant difference between the total scores of TCM syndromes before treatment(p>0.05);the difference between the total scores of symptoms after treatment is significant(p<0.05).Pairwise comparison,There was no significant difference between group A and group B(p>0.05),and group C had significant difference compared with group A and B(p<0.05).2.Bone marrow suppression:(1)Before treatment:The WBC,HB and PLT values of the three groups were not statistically significant(p>0.05);(2)After treatment:On the 8th and15th days of treatment,the differences in the WBC,HB and PLT values of the three groups were all Significance(p<0.05);further pairwise comparison,in which there is no significant difference between group A and group B(p>0.05),group C is significantly different from group A and group B(p<0.05);(3)The incidence of myelosuppression:compare the incidence of myelosuppression of WBC,HB and PLT in the three groups during the treatment process,of which WBC and HB are significant in the incidence of myelosuppression on the 8th and15th days(p<0.05),further pairwise comparison,the A and B groups were not statistically significant(p>0.05),and group C had significant difference compared with group A and B(p<0.05);PLT In the incidence of bone marrow suppression,the three groups of values on8th day were not statistically significant(p>0.05);the occurrence of PLT bone marrow suppression on 15th day was statistically significant(p<0.05),further pairwise comparison,the A and B groups were not statistically significant(p>0.05),and group C had significant difference compared with group A and B(p<0.05);3.In terms of T lymphocyte subsets:(1)Before treatment,there was no significant difference in the values of CD3~+,CD4~+,CD8~+and CD4~+/CD8~+among the three groups,(all p>0.05);(2)The CD3~+,CD4~+,and CD4~+/CD8~+values of the three groups increased after treatment,and CD8~+decreased,and the three groups differences are significant(p<0.05);Further pairwise comparison,there was no significant difference between groups A and B(p>0.05),and group C had significant difference compared with group A and B(p<0.05);(3)The three groups were compared before and after treatment,and the difference was significant(p<0.05);4.KPS score:The difference between the three groups in improving KPS score was statistically significant after treatment,p<0.05,further pairwise comparison,there was no significant difference between groups A and B(p>0.05),and group C had significant difference compared with group A and B(p<0.05).5.Safety index:The values of the three groups before and after treatment were not statistically significant,p>0.05.Conclusion:1.For patients with advanced lung and spleen Qi deficiency type NSCLC,Du Meridian Moxibustion combined with Shenqi Fuzheng Injection can significantly relieve shortness of breath,spontaneous sweating,fatigue,lack of appetite,abdominal distension,and abnormal stool,but it has no advantage in improving cough and sputum;Shenqi Fuzheng Injection is more effective than Du Meridian Moxibustion in terms of lack of appetite,abdominal distension,and abnormal stool.2.Du Meridian Moxibustion combined with Shenqi Fuzheng Injection can effectively reduce the incidence of bone marrow suppression during chemotherapy,mainly manifested in the protection and promotion of WBC,HB and PLT,and the effect is better than the applied Du Meridian Moxibustion group and Shenqi Fuzheng Injection group.3.Du Meridian Moxibustion,Shenqi Fuzheng Injection can significantly improve the immunity level of patients with chemotherapy.The combined application of the two drugs is superior to the application of Du Meridian Moxibustion group and Shenqi Fuzheng Injection group alone.4.Du Meridian Moxibustion,Shenqi Fuzheng Injection and the combination of the two drugs can improve the KPS scores of the patient,improve the quality of life,and have high safety.The combination of internal and external treatment of the two drugs is more effective and worthy of clinical promotion. |
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