Study On The Correlation Between Microalbuminuria And Simple Obesity-related Renal Injury In Children

Objective:Microalbuminuria(MAU)is a laboratory indicator for clinical diagnosis of early renal injury.In this study,we observed the changes in MAU of children with simple obesity from 4 to 16 years old,To explore the correlation between MAU and physical measurement indexes,blood glucose,blood lipid metabolism,and treat obese children with abnormal MAU for 6 months,observe the changes of MAU before and after treatment,To study the clinical application value of MAU in early renal impairment in children with simple obesity.Method:From November 2019 to March 2021,111 children with simple obesity(diagnosed by Department of Endocrinology,Metabolism and Genetics,Jiangxi Provincial Children’s Hospital,55 cases in the mild-to-moderate group and 56 cases in the severe group),46 healthy children of normal weight(visited by the Child Health Department of Jiangxi Provincial Children’s Hospital).They were aged from 4to 16 years old,and were measured by professional doctors,such as body mass index(BMI),waist circumference(WC),hip circumference(HC),waist circumference/hip circumference(W/H),systolic blood pressure(SBP),diastolic blood pressure(DBP),MAU and other indexes such as c-peptide(C-P),insulin(INS),fasting blood glucose(FBG),hemoglobin A1C(Hb A1c),serum Creatinine(SCr),blood urea nitrogen(BUN),total cholesterol(TC),triglyceride(TG),free fatty acid(FFA),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)were determined by laboratory.Eight obese children with abnormal MAU were followed up for 6 months to review MAU.Result:1.There were significant differences in BMI,BMISDS,WC,HC,SBP,DBP,SBP-SDS,DBP-SDS,TC,TG,MAU and INS between the obese group and the control group(P < 0.001),and the severe group was higher than the mild to moderate group(P < 0.001);There were significant differences in W/H,FBG,homeostasis model assessment insulin resistance(HOMA-IR),Hb A1 c,FFA,HDL-C,and LDL-C in obese children from the control group(P < 0.001).Compared with the control group,there was significant difference in SCr of obese children in each group(P <0.05),but it was within the normal range;there was no significant difference in BUN among the groups(P > 0.05).2.There was a positive correlation between MAU level and BMI,BMISDS,SBP,SBP-SDS,WC,HC,TC,TG in obese children(P < 0.001);there was no statistical correlation between MAU level and W/H,DBP,DBP-SDS,FBG,2-hour blood glucose,Hb A1 c,INS,HOMA-IR,C-P,SCR,BUN,HDL-C,LDL-C in obese children(P > 0.05).3.The MAU level of obese children after treatment was lower than that before treatment(P < 0.001).Conclusion1.The MAU level of obese children is higher than that of normal children,suggesting that simple obesity may cause early renal damage in children.2.MAU was positively correlated with BMI,SBP,TG and TC in obese children,suggesting that high BMI,hypertension and hyperlipidemia may be the risk factors of early renal injury in simple obese children.3.The MAU level of obese children after treatment is lower than before treatment,suggesting that early renal injury in obese children may be reversible,and active treatment is meaningful.