Efficacy Of Clonidine Transdermal Patch Combined With Tiapride Hydrochloride In The Treatment Of Tic Disorders In Children

Objective Tic disorder(TD)is a kind of onset mostly in childhood,the main characteristics are involuntary,repetitive,sudden,rapid;repetitive,non-rhythmic muscle twitching and(or)vocal twitching of one or more parts.Including transient tic disorder,chronic movement or vocal tic disorder,vocal tic disorder in combination with multiple movements.It can also suffer from attention deficit hyperactivity disorder(ADHD),learning difficulties(LD),sleep disorders(SD),emotional disorder(ED),obsessive-compulsive disorders(OCD)and other situations.After the onset of tic disorder,it is difficult to self-control,which will cause certain confusion to the children’s study,life,social interaction,etc.and seriously reduce the quality of life of the children.If the disease continues to progress,the disease may also cause certain harm to the society.Gradually developed into constant profanity,self-harm,self-abuse,molestation,etc.The main purposes of this study are: 1.Comprehensively compare the efficacy of the two medication regimens from multiple aspects,and find a more optimized medication regimen for the treatment of tic disorder.2.In the later stage,based on the results of the research,we can see whether it can be further studied.More different treatment options with better curative effect.Methods1.Select 100 children with tic disorder who came to our hospital for treatment.Inclusion criteria: The diagnosis of all enrolled children must meet the diagnostic criteria of the "Expert Consensus on the Diagnosis and Treatment of Children’s Tic Disorders" 2017 Practical Edition.Exclusion criteria: Exclude obsessive-compulsive disorder,schizophrenia-like disorder,mental development disorder,autism spectrum disorder,epilepsy,rheumatic chorea,extrapyramidal diseases,attention deficit hyperactivity disorder,drug-induced tics,etc.that can cause children Involuntary tics.2.Randomly divided into 50 cases in the control group(single use of tiapride hydrochloride)and 50 cases in the observation group(tiopride hydrochloride combined with clonidine transdermal patch).After grouping,statistics require that the two groups of children have no significant differences in general information such as age,gender,and disease course(P>0.05).3.Judging the efficacy of the drug by observing the comprehensive situation of the onset time,control time,effective rate,and adverse reactions after the child’s medication.Results1.The short-term treatment effect of the observation group is better than that of the control group.2.The onset time of the observation group was faster than that of the control group.3.The control time of the observation group was earlier than that of the control group.4.The effective rate of observation group was similar to that of control group.5.Compared with the control group,the side effects of the observation group did not increase,and no serious adverse reactions occurred.Conclusion The efficacy of tiapride hydrochloride combined with clonidine transdermal patch in the treatment of tic disorders in children is better than that of tiapride hydrochloride alone.Mainly reflected in the following aspects: the short-term therapeutic effect of the combination drug is better than that of the single drug;The onset time of combination medication is faster than single medication;Combination medication takes shorter time to control the condition than single medication;the effective rate of combined medication is similar to that of single medication;The adverse reactions of the combination medication did not increase compared with the single medication,and no serious adverse reactions occurred.