| Objective:To observe and evaluate the clinical efficacy of Jianpi Zhuyun Decoction on infantile anorexia(spleen and stomach qi deficiency syndrome),and observe its effectiveness;preliminary exploration of the mucosal immune mechanism of Jianpi Zhuyun Decoction in the treatment of infantile anorexia,for the treatment of children with Jianpi Zhuyun Decoction Anorexia(spleen-stomach-qi deficiency syndrome)provides more evidence support,and provides new ideas and new methods for the treatment of infantile anorexia.Methods: This study screened and collected 60 children with anorexia(spleen and stomach qi deficiency)who met the criteria.According to the random number table,20 patients were randomly divided into Chinese medicine group、Western medicine group as well as Chinese and Western medicine combination,and were respectively treated with Jianpi Zhuyun Decoction,Shiyi treatment,and Jianpi Zhuyun Decoction + Shiyi treatment.,three groups of treatment courses are 4 weeks,record the changes in the TCM syndrome scores of the three groups of patients before treatment,2 weeks of treatment,and 4 weeks of treatment.Saliva before treatment and 2 weeks after treatment is taken to detect the SIg A content.After 3months,a telephone follow-up was conducted to observe the recurrence rate.Result:1General situation: Among 60 children with anorexia,20 were women(33.33%)and 40 were men(66.67%);the onset age was more common in school age(3-7 years old);the course of the disease was more than 1 year(76.67%);eating habits: 11 cases(18.3%)with normal eating habits,30 cases(50%)with picky eaters,11 cases(18.3%)with binge eaters,both overeating and picky eaters 8 cases(13.3%);diet structure: 19 cases(31.67%)with reasonable diet,24 cases(40.0%)with high protein,12 cases(20.00%)with high sugar content,and 5cases with multiple factors(8.33%).2 Total effective rate analysis Comparison of the effect of appetite in the three groups of children with anorexia: the traditional Chinese medicine group is 85%,the western medicine group is 45%,and the combined Chinese and western medicine group is 90%.The main difference between the three groups is whether the symptoms of loss of appetite disappear or not.There is a significant difference in the effect of appetite between the three groups statistically significant(P<0.01).The results of the curative effect analysis of the three groups of TCM syndrome scales indicate that the total effective rate of the combined Chinese and Western medicine group is95%,the Chinese medicine group is 90%,and the western medicine group is 60%.The difference in curative effect of the three groups of TCM syndromes was statistically significant(P<0.01).3 Syndrome integral analysis(1)Analysis within the group(1)In the traditional Chinese medicine group,the scores of appetite,food intake,stool,restless night sleep,abdominal distension,fatigue,and hiccups were improved compared with before treatment in the traditional Chinese medicine group(P﹤0.05).There was no statistical difference in weight loss and complexion scores.P>0.05);After 4 weeks of treatment,the children’s appetite,food intake,stool,restless night sleep,abdominal distension,hiccups,complexion,and fatigue scores were significantly improved compared to before treatment(P﹤0.01),and there was no statistical difference in body weight loss scores(P> 0.05).(2)In the western medicine group,the scores of appetite,defecation,food intake,hiccups and restlessness at night were improved compared to before treatment,with a statistical difference(P﹤0.05);after 4 weeks of treatment,appetite,food intake,hiccups,restlessness at night,and stool The score was improved compared with before treatment,with a statistical difference(P﹤0.05).During the treatment period,there was no statistical difference in body weight loss,complexion,fatigue,and abdominal distension scores(P>0.05)(3)After 2 and 4 weeks of treatment in the combined Chinese and Western treatment group,the children’s appetite,food intake,stool,restless night sleep,abdominal distension,complexion,hiccups,and fatigue scores improved compared to before treatment,with significant statistical differences(P﹤0.05),and no body weight loss scores Statistical difference(P>0.05).The above data shows that the combination of Jianpi Zhuyun Decoction,Shiyi,and Jianpi Zhuyun Decoction can improve the appetite,food intake,hiccups,restlessness,and bowel movements of children during the treatment period.In addition,the combination of Jianpi Zhuyun Decoction and Jianpi Zhuyun Decoction can also improve the abdominal distension,fatigue and complexion of children.(2)Analysis between groups(1)After 2 weeks of treatment,there were statistically significant differences in appetite,food intake,fatigue,abdominal distension,hiccups,and restless night scores in the three groups(P﹤0.05),but no statistical differences in body shape,complexion,and stool(P>0.05).After pairwise comparisons,compaired with the western medicine group the scores of appetite and fatigue in the Chinese medicine group were significantly different(P﹤0.05),and the scores of food intake,fatigue,hiccups and hiccups in the combined Chinese and western medicine group were significantly different(P﹤0.05).(2)After 4 weeks of treatment,there were significant differences in appetite and fatigue scores among the three groups(P﹤0.01).There were statistical differences in food intake,abdominal distension,hiccups,and restlessness scores at night(P﹤0.05).There were no statistical differences in body shape,complexion,and stool.(P>0.05).After pairwise comparisons,compared with the western medicine group,the scores of fatigue,appetite,abdominal distension,and restlessness in the traditional Chinese medicine group were statistically different(P﹤0.05);the scores of fatigue,hiccups,appetite,food intake,abdominal distension,and restless night sleep were not statistically significant in the combined Chinese and Western medicine group,academic difference(P﹤0.05).After 2 weeks of treatment,Jianpi Zhuyun Decoction can effectively improve the children’s appetite and fatigue score.The Chinese and Western combination group can effectively improve the children’s appetite,fatigue,and hiccup score,the western medicine group;in the 4 weeks of treatment,the Jianpi Zhuyun soup can effectively improve fatigue,appetite,and abdominal distension scores.The combination of Chinese and Western medicine can effectively improve the children’s appetite,food intake,abdominal distension,restless night sleep,fatigue,and hiccup scores,which is better than the western medicine group;treatment for 2 and 4 weeks,there is no statistical difference in the improvement of stool in the three groups(P>0.05),suggesting that all three groups can effectively improve the stool condition of children,and the three groups are equivalent.4 Saliva SIg A content: Compared within 2 weeks of treatment,the saliva SIg A content,P<0.05,is statistically different.The comparison between the groups P>0.05,there was no statistical difference.After the three methods of treatment,the SIg A content of the children decreased,but there was no statistical difference between the three,indicating that the three groups have the same curative effect and equivalent.It is speculated that Jianpi Zhuyun Decoction can reduce the saliva SIg A content and regulate mucosal immunityand treatment of infantile anorexia(spleen and stomach qi deficiency syndrome).5 The children in this study were followed up by phone for 3 months after treatment.There were 3 relapses in the Chinese and Western medicine group;3 cases in the Chinese medicine group;and 10 cases in the Western medicine group.According to statistical analysis,P<0.05,the difference was statistically significant.Conclusion:1 Jianpi Zhuyun Decoction can effectively treat infantile anorexia(spleen and stomach qi deficiency syndrome).The appetite curative effect and TCM syndrome curative effect of Jianpi Zhuyun Decoction are better than Shiyi,and the combination of Jianpi Zhuyun Decoction and Yiyi has the appetite curative effect and TCM syndromes.The curative effect is better than single use of Jianpi Zhuyun Decoction or Shiyi.2 Chinese medicine dialectics is anorexia(spleen and stomach qi deficiency syndrome),the use of Jianpi Zhuyun Decoction has a positive therapeutic effect,and it can improve fatigue,appetite,abdominal distension,and scores of the children compared with the western medicine group.The combination of the two can improve the appetite,food intake,and food intake of the children.The scores of abdominal distension,restless night sleep,fatigue,and hiccup were better than those of the western medicine group.The stool scores of the three groups all improved,suggesting that the three groups can effectively improve the stool condition of the children,and the three groups are equivalent.3 Saliva SIg A content,:it is speculated that Jianpi Zhuyun Decoction can reduce the saliva SIg A content,improve the body’s mucosal immune function,and treat anorexia(spleen and stomach Qi deficiency)certificate). |
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