Clinical Observation On The Compound Allergic Decoction In Cough Variant Asthma With Fengxie-Fanfei Syndrome

Objective This study was conducted in a randomized controlled trial to objectively evaluate the clinical efficacy and safety of Compound Allergy Decoction in the treatment of patients with cough variant asthma with Fengxie-Fanfei syndrome.Methods 60 patients with cough variant asthma with Fengxie-Fanfei syndrome in the outpatients of traditional Chinese Medicine Hospital of Inner Mongolia Autonomous Region from January 2020 to December 2020 were selected as the observation objects in this study,and the randomized,controlled clinical trial design methed was adopted.The patients were randomly divided into the experimental group and the control group by the random number table method.A total of 60 patients were included,including30 in the experimental group and 30 in the control group.The experimental group was given Compound Allergic Decoction,and the control group was given Montelukast Sodium Tablets.The course of treatment was 4weeks.The first drug dilivery,4 weeks were taken as the observation nodes.The clinical efficacy and safety of Compound Allergy Decoction were evaluated by the indicators including TCM syndrome score,cough symptoms score,visual analogue scale,Leicester Cough Questionnaire(LCQ),breath nitric oxide(Fe NO),pulmonary function testing related indicators(FEV1%and PEF%),the value of serum Ig E,security index and the relapse after 4 weeks.Results1.TCM syndrome scores and individual scores: After treatment,the scores of cough,itching pharynx,shortness of breath,sneezing and total scores in the experimental group and the control group were significantly lower than before treatment(P<0.05),and the scores of experimental group was significantly lower than the control group(P<0.05).2.Cough symptom scores: After treatment,the total scores of daytime and night cough and cough symptoms were significantly lower than those before treatment(P<0.05);Among them,there was no significant difference between the daytime cough group.The total score of night cough and cough symptom in experimental group was significantly lower than that in control group.3.Visual analogue scale: After treatment,the VAS in the experimental group and the control group was significantly lower than that before treatment(P<0.05),and the the scores of VAS in the experimental group was significantly lower than that in the control group(P<0.05).4.Leicester Cough Questionnaire(LCQ): After treatment,the LCQ physiological region scores,psychological region scores,social region scores and total scores in two groups were significantly higher than before treatment(P<0.05),and the LCQ physiological region scores,psychological region scores,social region scores and total scores in the experimental group were significantly higher than those in the control group(P<0.05).5.Exhaled nitric oxide(Fe NO)and serum Ig E: After treatment,Fe NO in experimental group and control group were significantly improved compared with before treatment(P<0.05),but there was no significant difference between groups(P>0.05).The scores of serum Ig E in both groups after treatment was significantly lower than before treatment,and the scores of experimental group was significantly lower than control group(P<0.05).6.Pulmonary function(FEV1% and PEF%)indexes: After treatment,pulmonary function(FEV1% and PEF%)in experimental group and control group was significantly higher than that before treatment(P<0.05),and that in experimental group was significantly higher than that in control group(P<0.05).7.Recurrence rate and safety: After 4 weeks of solstice treatment,the recurrence rate was 36.7% in the control group and 13.3% in the experimental group.No abnormalities were found in the related safety indicators of the two groups and no adverse reactions occurred.Conclusions Compound Allergy Decoction can more effectively improve the clinical syndrome manifestation,quality of life,lung function and serum Ig E level of patients with cough variant asthma with Fengxie-Fanfei syndrome.At the same time,compound allergy decoction has a definite effect on reducing the recent cough recurrence rate of patients with Fe NO and CVA,and has no obvious abnormal adverse reactions.