Research On Analgesic Mechanism And Evaluation Of Transcutaneous Electrical Acupoint Stimulation Based On EEG Analysis

Acupuncture is a treatment method for diseases with distinctive Chinese characteristics,which has been highly praised by many scholars at home and abroad in recent years.However,the scientific basis of acupuncture is incomplete,which limits its development.So it is important to explore the underlying principles of acupuncture.A large number of studies have shown that acupuncture is effective in analgesics,and that pain stimulation and acupuncture overlap in the activated area of the cerebral cortex.This dissertation starts with pain stimulation-induced EEG signals,and uses Transcutaneous Electrical Acupoint Stimulation(TEAS),which is easy to set objective acupuncture parameters,as an acupuncture method to explore the analgesic mechanism of acupuncture.In the aspect of pain evaluation,the subjective index of VAS is widely used in clinical practice and lacks objective parameters.This dissertation further explores the EEG characteristic parameters used to evaluate the analgesic effect of TEAS.First of all,This dissertation verified that TEAS has an effect on brain status,and EEG signals are clearly separable.Hegu(Li4),which is widely used in clinic and has significant analgesic effects,is used for the stimulation of acupoints.The experimental results show that TEAS has a greater impact on the high-frequency energy of the EEG signal,and the average accuracy rate of the three classifications is as high as 93%.This shows that TEAS does cause changes in brain functional activity.Secondly,This dissertation explores the analgesic mechanism of TEAS.By comparing the characteristics of EEG signals induced by electrical stimulation before and after TEAS stimulation,the mechanism of TEAS analgesia was explored.In addition,this study set the pain threshold stimulation control group to eliminate the interference of current and other factors in pain stimulation.The experimental results found that before TEAS stimulation,the left temporal lobe,left central lobe,and left parietal lobe induced relatively obvious ERD phenomena at 32 Hz and 48 Hz,and ERD disappeared after TEAS stimulation,and the ERD characteristics were significantly different compared with the control.Furthermore,after TEAS stimulation,the paininduced stimulation of alpha band ERD is stronger and the range is wider.The results indicate that TEAS stimulation can reduce the high-frequency pain characteristics of the left temporal lobe,left parietal lobe,and left central lobe.After TEAS stimulation,more brain areas are involved in the pain management process,and these brain areas respond more actively than before TEAS stimulation.Finally,the subjects were ranked according to their subjective analgesic effect.The frequency feature,time-frequency feature,and Spectral Edgy Frequency feature(SEF)were compared with the ranking of 15 subjects for regression analysis.The experimental results show that the resting state FPZ’s PSD changes,the FC3 F3’s ERSP changes,FPZ FP1’s SEF changes show a strong correlation with subject ranking.This dissertation has carried out multiple groups of research around TEAS stimulation,explained the analgesic mechanism of TEAS in the cerebral cortex,and explored objective EEG parameters to evaluate the analgesic effect of TEAS.It provides a basis for the theoretical study of acupuncture and traditional Chinese medicine and the objective parameters of analgesia.