| Objective This article aims to observe the clinical efficacy and safety of Wenzhongxiaopi Decoction in the treatment of functional dyspepsia of spleen-stomach deficiency and cold type,as well as observe the improve anxiety and depression status of the patients.Meanwhile we investigate the effects of Wenzhongxiaopi decoction on serum motility and gastrin levels among patients with functional dyspepsia of spleen-stomach deficiency and cold type,and to explore the possible mechanism of its treatment of functional dyspepsia.Methods Choosing 68 patients diagnosed with functional dyspepsia with spleen-stomach deficiency and cold type treated in Academy of Traditional Chinese Medicine from January 2020 to December 2020,according to the order to the patient,using the random number table method were randomly divided into treatment group and control group,34 cases in each group.The treatment group was given oral Wenzhongxiaopi decoction for 4 weeks,and the object group was given oral Mosapride citrate tablets for the same time.After the treatment,the changes of TCM syndrome score,single symptom score,serum motilin(MTL),serum gastrin(GAS),Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)in 2 groups were observed.After 2 months of treatment,patients who were clinically cured,significantly effective and effective were followed up to observe and compare the recurrence rate between the two groups.According to compare with the patients’ vital signs,physical examination,routine blood test,routine urine test,liver function and kidney function results before and after treatment,and whether there were adverse reactions during medication,the safety was evaluated.Results A total of 68 patients with functional dyspepsia of spleen-stomach deficiency and cold type were included in this study,including 34 patients in the treatment group and 34 patients in the control group.Doctor-patient communication was strengthened during the treatment period,and all the patients participated in the whole study without shedding or excluding cases.1.Comparison of general data: Statistical analysis was conducted on the general data of patients in the two groups,such as gender,age,course of disease,TCM syndrome score and single symptom score before treatment,and there was no statistical difference(P>0.05),indicating comparability.2.Comparison of curative effect: Comparison of curative effect: the total effective rate of the treatment group was 88.23%,and the total effective rate of the control group was 76.47%.There was a statistical difference in the overall curative effect between the two groups(P<0.05),the curative effect of the treatment group was better than the control group.Comparison of TCM syndrome scores: after treatment,TCM syndrome scores of the two groups were significantly decreased(P<0.05);In addition,the improvement of clinical symptoms was more obvious in the treatment group(P<0.05).3.Single syndrome integral comparison: After treatment,the main symptoms and secondary symptoms of the treatment group were significantly improved(P<0.05);In the control group,the symptoms of epigastric pain or epigastric fullness and distention,vomiting of clear water,loss of appetite,tiredness and lack of power were significantly improved(P<0.05),but there was not improvement in epigastric warm and press,cold limb,loose stool(P>0.05).4.Comparison of mental state scores: Before treatment,there was no statistical difference in the scores of anxiety and depression scales between the two groups(P>0.05),indicating comparability.After treatment,anxiety and depression in 2 groups were improved compared with before(P<0.05),and anxiety and depression scale scores in the treatment group were decreased more significantly than those in the control group(P<0.05).5.Comparison of serum MTL and GAS secretion levels: There was no statistical significance in the detection values of MTL and GAS between the two groups before treatment(P>0.05).After treatment,the serum MTL and GAS values in both groups were significantly higher than before(P<0.05);In addition,the increase of serum MTL and GAS in the treatment group was more obvious(P<0.05).6.Comparison of recurrence occurs: After the end of treatment,patients were followed up by telephone for 2 months.The long-term efficacy of the treatment group was better than that of the control group(P<0.05).Conclusion1.Wenzhong Xiaopi Decoction treating spleen-stomach type cold functional dyspepsia are safe and effective,the clinical symptoms were significantly improved,and has certain effect on reducing the recurrence rate of this disease.2.Wenzhongxiaopi decoction can increase the levels of motilin and gastrin in patients’ serum,which one of the mechanisms of Wenzhongxiaopi decoction in treating functional dyspepsia of spleen-stomach deficiency and cold type. |
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