Research On Medication Rule And Meta-analysis Of Traditional Chinese Medicine In Treating Ulcerative Colitis With Damp-heat Syndrome Of Large Intestine Based On Data Mining

Objective Applying data mining technology to study the prescription and medication rules of traditional Chinese medicine in the treatment of UC large intestine damp-heat syndrome,and providing objective basis and dialectical thinking for clinical diagnosis and treatment,and use meta-analysis to study the clinical efficacy of traditional Chinese medicine combined with western medicine in the treatment of UC large intestine damp-heat syndrome,in order to provide evidence-based medical evidence for clinical application.Methods Through the database of CNKI,Wanfang,and CBM,retrieve the relevant literature on the treatment of UC large intestine damp-heat syndrome with traditional Chinese medicine,screen the prescription and establish the database according to the inclusion criteria,apply the traditional Chinese medicine inheritance computing platform(V3.0),and use the frequency statistics,association rule analysis,cluster analysis and other methods in the software to statistics and collate the data,so as to obtain the prescription and medication rules for clinical diagnosis and treatment of UC damp-heat syndrome of large intestine.Meta analysis included RCTs literature that met the criteria of traditional Chinese medicine combined with western medicine in the treatment of UC damp-heat syndrome of large intestine compared with western medicine alone by searching the databases of CNKI,Wanfang,VIP,and CBM,using the Cochrane evaluation method to evaluate the quality of the included documents,and using Rev Man 5.4 software to conduct data research on the included RCTs literature.Results1.Data mining research: 176 prescriptions were collected and analyzed by using the traditional Chinese medicine inheritance computing platform.The drugs used to treat UC large intestine damp-heat syndrome were bitter and cold,and the meridians of the spleen,stomach,liver,large intestine and lung.In the correlation analysis,the main drugs were coptis chinensis,Radix Aucklandiae,white peony,scutellaria baicalensis,licorice,angelica sinensis,Pulsatilla chinensis,phellodendron amurense,and atractylodes macrocephala.The high-frequency drug pairs included Coptis chinensis-Radix Aucklandiae,scutellaria baicalensis-white peony,coptis chinensis-white peony,Radix Aucklandiae-white peony,Scutellaria baicalensis-Coptis chinensis,Angelica-Paeonia lactiflora,Coptis chinensis-Cortex phellodendri,Pulsatilla chinensis-Cortex fraxini,Radix Aucklandiae-betel nut;Special drug pairs include Coptis chinensis-Cinnamomum cassia,Lily-Perilla leaf,Panax notoginseng-white ginger,Sanguisorba officinalis-Sophora japonica.Four core combinations were obtained by cluster analysis:(1)Licorice,coptis chinensis,Radix Aucklandiae,white peony,scutellaria baicalensis,angelica;(2)Coptis chinensis,Radix Aucklandiae,licorice,purslane,atractylodes macrocephala,phellodendron amurense,(3)Coptis chinensis,Pulsatilla chinensis,Cortex Fraxini,Cortex Phellodendri,Radix Aucklandiae,Licorice;(4)Coptis chinensis,licorice,kudzu root,scutellaria baicalensis,Pulsatilla chinensis,Radix Aucklandiae.2.Meta analysis: A total of 12 studies were included.The results of meta-analysis showed that:(1)compared with the use of western medicine alone,traditional Chinese medicine combined with western medicine has better clinical efficacy in treating UC large intestine damp-heat syndrome;(2)Traditional Chinese medicine combined with western medicine can better reduce the symptom score of traditional Chinese medicine in the treatment of UC large intestine damp-heat syndrome;(3)Traditional Chinese medicine combined with western medicine can better reduce the score of intestinal mucosa in UC with damp-heat syndrome of large intestine;(4)Traditional Chinese medicine combined with western medicine can better improve the level of inflammatory factors in the treatment of UC large intestine damp-heat syndrome;(5)The combination of traditional Chinese medicine and western medicine in the treatment of UC large intestine damp-heat syndrome is safe and has a low recurrence rate;(6)Funnel chart analysis showed that there was publication bias.Conclusion1.Clinically,UC large intestine damp-heat syndrome is characterized by a mixture of deficiency and excess.The pathological elements are mainly damp-heat,deficiency of qi,stagnation of qi,blood stasis(or blood heat).The treatment is mainly to clear heat and dry dampness,replenish qi and warm yang,regulate qi and remove stasis and stop bleeding.The characteristics of medication are to clear and warm,regulate cold and heat,treat both qi and blood,and give consideration to both evil and positive.Commonly used drugs include coptis chinensis,Radix Aucklandiae,white peony,scutellaria baicalensis,licorice,angelica sinensis,Pulsatilla chinensis,phellodendron amurense,and atractylodes macrocephala,etc.The prescription is mainly peony soup,Xianglian pill,Pulsatilla soup,Gegen Qinlian Decoction.2.The combination of traditional Chinese medicine and western medicine in the treatment of UC large intestine damp-heat syndrome can better improve the clinical efficacy,relieve the symptoms of traditional Chinese medicine,reduce the score of enteroscopy mucosa,improve the level of inflammatory factors,and has the advantages of good safety and low recurrence rate,but the research results have certain risks,which need to be further verified.