Based On The Ancient And Modern Medical Record Cloud Platform System To Analyze The Symptoms And Medication Rules Of Traditional Chinese Medicine In The Treatment Of Interstitial Lung Disease

Objective:Based on the ancient and modern medical record cloud platform,through data mining technology,the medication rules of traditional Chinese medicine in the treatment of ILD are analyzed,and the ideas for clinical diagnosis and treatment of ILD are broadened.Methods:Through the computer comprehensive search of CNKI,VIP,Wan Fang Data and CBM,the clinical literature on the treatment of ILD with traditional Chinese medicine published in January 2022,and the clinical medical records that meet the standards were screened.The patient’s name,gender,age,clinical manifestations,tongue quality,tongue coating,pulse condition,TCM syndrome,treatment method,TCM composition,TCM dosage and other information were counted,and a database was established,using Microsoft Excel,ancient and modern medical record cloud platform,and SPSS Modeler18,Cytoscape＿3.7.2 software for frequency statistics,association rules,hierarchical clustering,complex network analysis and picture visualization.Results:1.Gender: The proportion of male patients is higher than that of female patients,and the ratio of male patients to female patients is about 1.61.2.Age: The age of the patients is 50-69 years old,accounting for 60.17% of the total.3.Four diagnosis information: the top 5 high-frequency tongue quality are: dark tongue,red tongue,pale tongue,purple tongue,and pale red tongue.The top 5 high-frequency tongue coating are:greasy tongue,yellow tongue,thin white tongue,white tongue,thin coating.The top 5 high-frequency pulse patterns are: stringy pulse,thin pulse,slippery pulse,pulse number and deep pulse.The top 5 high-frequency clinical symptoms were cough,asthma,chest tightness,shortness of breath,and white sputum.The top 5in the comprehensive frequency distribution of the four diagnostic information were cough（98 times）,asthma（69 times）,dark tongue（68 times）,chest tightness（61 times）,and red tongue（59 times）.4.Association rules of clinical symptoms: high-frequency clinical symptoms are roughly divided into three categories: the first category can be analyzed as pulmonary atrophy mainly due to yin deficiency: suffocation,dry throat,dry cough,sputum less and thin;The main symptoms of phlegm-heat were analyzed: insomnia,heart palpitations,yellow sputum,thick phlegm;the third category was general clinical manifestations of pulmonary wilt: asthma,cough,chest tightness,white sputum,sticky sputum difficult to cough,shortness of breath,spitting,dry mouth,fatigue,poor appetite,shortness of breath,blue lips.5.TCM symptoms: the top 5 are the syndrome of phlegm and blood stasis blocking the lung,the syndrome of deficiency of lung-kidney qi,the syndrome of deficiency of both lung-qi and yin,the syndrome of blood stasis blocking the lung collaterals,and the syndrome of phlegm blocking the lung.6.TCM symptom-clinical symptom correlation analysis: The clinical symptoms that are closely related to lung stasis syndrome are: cough,shortness of breath,wheezing,shortness of breath,fatigue,dry cough,fatigue,chest tightness.The closely related clinical symptoms of phlegm obstruction lung syndrome are: cough,asthma,shortness of breath,white sputum,loose stools,difficult phlegm,and chest tightness.The closely related clinical symptoms of Phlegm and Stasis Lung syndrome : cough,asthma,chest tightness,shortness of breath,white phlegm,suffocation,dry mouth,fatigue,and difficulty in sticking phlegm.The clinical symptoms of phlegmheat blocking lung syndrome are closely related: asthma,cough,yellow phlegm,chest tightness,phlegm sticking,shortness of breath,shortness of breath,insomnia,fatigue,suffocation,and dry mouth.Clinical symptoms closely related to lung-kidney qi deficiency : cough,asthma,shortness of breath,fatigue,white sputum,fatigue,shortness of breath.The closely related clinical symptoms of Qi stagnation syndrome are: chest tightness.The closely related clinical symptoms of Qi deficiency and blood stasis syndrome are cough,asthma,and chest tightness.The closely related clinical symptoms of lung-yin deficiency syndrome are:cough.The clinical symptoms closely related to lung-kidney-yang deficiency syndrome are cough.The clinical symptoms that are closely related to deficiency of both lung,qi and yin are: cough,asthma,dry mouth,shortness of breath,fatigue,chest tightness,dry throat,suffocation,shortness of breath,and difficulty in sticking phlegm.The closely related clinical symptoms of lung-qi deficiency syndrome are cough,wheezing,and chest tightness.7.Syndrome element-Statistical analysis of disease location:The top 5 high frequency disease locations are lung,kidney,spleen,liver,and rib.8.Statistical analysis of syndrome elements-pathological factors: The top 5 high-frequency pathological factors were phlegm,blood stasis,qi deficiency,heat,and yin deficiency.9.Frequency of medication : 123 prescriptions contain a total of 261 Chinese herbal medicines,and the total frequency of medication is 1895.The top 30 flavors of medication frequency are Pinellia,Salvia,Scutellaria,Perilla,Poria,Schisandra,Platycodon,Ophiopogon,tangerine peel,Ma Huang,Peach Kernel,Codonopsis,Aster,Angelica,Zhe Fritillaria,Dilong,Chuanxiong,Atractylodes,Mulberry,Sanleng,dogwood,houttuynia cordata,golden buckwheat,loquat leaves,curcuma,cicada slough,melon,the cumulative frequency of 959 times,accounting for 50.61% of the total frequency of medication.10.Odor returns to meridian: Among the four qi used in the 123 prescriptions,the warm herbs were used the most,with a frequency of 504 times,accounting for 26.60% of the total,followed by the flat herbs,with a frequency of 428 times,accounting for 22.59%of the total.The five flavors in the traditional Chinese medicine used were mainly sweet,bitter and acrid,and the frequencies were853 times,749 times and 692 times respectively,accounting for45.01%,39.53% and 36.52% of the total.Lung meridian drugs were used the most,with a frequency of 1105 times,accounting for 58.31%of the total,followed by spleen meridian and liver meridian drugs,with a frequency of 643 times and 589 times,accounting for 33.93%and 31.08% of the total.11.Efficacy:Statistics on the efficacy of traditional Chinese medicines in 123 prescriptions found that the most frequently used traditional Chinese medicines were clearing heat and detoxifying,followed by laxatives,diuresis and swelling,dampness and phlegm.12.Association rules of traditional Chinese medicine:123prescriptions were set with confidence > 0.7 and support > 0.1,and obtained 18 association rules of traditional Chinese medicine combinations.Among them,the valuable drug combinations are:tangerine peel-Pinellia,Codonopsis-Astragalus,Campanulaceae-Licorice,Ephedra-Bitter almond,Loquat leaf-Bitter almond,Curcuma-Sanleng,Cicada slough-Bitter almond,Chinese yam-Astragalus,Rehmannia-Astragalus Wait.13.TCM Syndrome-TCM Correlation Analysis: The association analysis between TCM syndromes and the use of traditional Chinese medicines in 123 medical records was carried out,and the confidence level was set to > 0.5 and the support degree was set to > 0.05,and 26 association rules were obtained.According to the more valuable association rules,the most commonly used drugs for deficiency of lung,qi and yin are: Ophiopogon japonicus,licorice,peach kernel,and schisandra.The most commonly used drugs for lungkidney qi deficiency are dogwood,bitter almond,perilla,astragalus,and schisandra.The most commonly used drugs for the syndrome of phlegm-heat blocking the lung are bitter almond,perilla,melon,licorice,platycodon,mulberry white bark,and skullcap.The most commonly used drugs for Qi deficiency and blood stasis syndrome are: Salvia miltiorrhiza.The most commonly used drugs for lung-qi deficiency are : licorice and astragalus.14.Cluster analysis of traditional Chinese medicine: perform cluster analysis on the top 30 traditional Chinese medicine information with the highest frequency of drug use.The clustering method is the longest distance method,and the distance type is set to Lance distance.High-frequency traditional Chinese medicine is roughly divided into two categories: the first category: ephedra,almond,licorice,mulberry,perilla,melon,tangerine peel,Pinellia,Poria,Atractylodes,Danshen,peach kernel,Chuanxiong,Angelica,Zhebei Mother,Campanulaceae,Codonopsis,Astragalus,Sanleng,Curcuma;the second category: Scutellaria,aster,Schisandra,Ophiopogon japonicus,Dilong,dogwood,cicada slough,loquat leaves,Houttuynia cordata,golden buckwheat.Then according to the thinking of traditional Chinese medicine,it can be divided into 10 sub-categories:（1）.Ephedra,bitter almond,licorice,mulberry,perilla,and melon.（2）Chenpi,Pinellia,Poria,Atractylodes.（3）.Salvia,peach kernel,Chuanxiong,Angelica.（4）Zhejiang Fritillaria,Platycodon grandiflorum.（5）Codonopsis,Astragalus.（6）Triangular,Curcuma.（7）Scutellaria and aster.（8）Schisandra,Ophiopogon japonicus.（9）Dogwood,earthworm,cicada slough,loquat leaves.（10）Houttuynia cordata and golden buckwheat.15.Complex Network Analysis:The core drug network for the treatment of ILD is mainly composed of licorice,astragalus,bitter almond,salvia,pinellia,perilla,scutellaria,and platycodon.Conclusion:The proportion of male patients with ILD is higher than that of female patients,and the most widely distributed age group is 50-69 years old.The etiology and pathogenesis analysis is as follows: often due to pathological factors such as phlegm,blood stasis,qi deficiency,heat and other pathological factors invading（or transferring to）the lung,kidney,spleen,liver and other viscera,the disease syndrome is a combination of deficiency and excess.In the treatment,the four qi are mainly warm and flat,and the five flavors are mainly sweet,bitter and acrid,which enter the lung,spleen and liver meridians.The medicine pairs often used in dialectics are tangerine peel-pinxia,codonopsis-astragalus,platycodon-licorice,ephedra-bitter almond,loquat leaf-bitter almond,curcuma-sanleng,cicada slough-bitter almond,yam-astragalus,rehmannia-astragalus,etc.The most common core drugs for the treatment of ILD are licorice,astragalus,bitter almond,salvia,pinellia,perilla,scutellaria,platycodon,aster,tuckahoe,Ophiopogon japonicus,peach kernel,ephedra,schisandra,tangerine peel,Houttuynia cordata,Codonopsis,etc.Compatibility has the functions of clearing heat and resolving phlegm,promoting blood circulation and removing blood stasis,dispelling and lowering lung qi,lowering qi and resolving phlegm,nourishing lung and spleen qi,invigorating spleen and removing dampness and resolving phlegm.It can be used as a reference for clinical dialectical treatment.