| This paper is divided into two parts:cross-sectional study and randomized controlled study.Clinical investagion Ⅰ:Clinical characteristics of TCM syndrome types of stable an gina pectorisObjective:To explore the TCM syndromes of patients with stable angina pectoris and their correlation with risk factors,so as to provide objective basis for the identification of their syndromes.Methods:The information of patients including age,gender,medical history,combination of drugs,smoking history,drinking history,four diagnostic information of traditional Chinese medicine,physical and chemical examination results were collected,referring to the guiding principles for clinical research of new drugs of traditional Chinese medicine(2002),internal medicine of traditional Chinese medicine(8th Edition),guidelines for diagnosis and treatment of stable angina pectoris of coronary heart disease(cardiovascular branch of Chinese society of traditional Chinese Medicine).The TCM syndrome types of patients with stable angina pectoris were divided into four types:phlegm and blood stasis type,qi stagnation and blood stasis type,Qi deficiency and blood stasis type and Qi and yin deficiency type.The basic information and physical and chemical results of patients were recorded in Excel and analyzed by SPSS.24.0.Results:The results showed that the distribution of TCM Syndromes of 194 patients with stable angina pectoris were as follows:86 cases of phlegm and blood stasis type,52 cases of qi deficiency and blood stasis type,29 cases of Qi and yin deficiency type,27 cases of qi stagnation and blood stasis type.There was significant difference in gender distribution among different syndrome types(p=0.016<0.05);BMI(b=0.616,p=0.000,or=1.851)and HGB(b=0.032,p=0.010,or=1.033)were the independent influencing factors of Phlegm Blood Stasis Syndrome;BMI was an independent factor of qi deficiency and blood stasis(b=-0.283,p=0.000,or=0.753);BMI was an independent factor of Qi and yin deficiency(p<0.05,B=-0.164,or=0.849).Conclusion:The distribution of TCM syndrome types of stable angina pectoris:phlegm and blood stasis type>Qi deficiency and blood stasis type>Qi Yin deficiency type>qi stagnation and blood stasis type;Gender,BMI,HGB were positively correlated with phlegm and blood stasis type,BMI was negatively correlated with qi stagnation and blood stasis type and Qi and yin deficiency type.Clinical investagion Ⅱ:Clinical observation of Danlou tablet interventionObjective:To observe the clinical effect of Danlou tablet in the treatment of stable angina pectoris with phlegm and blood stasis syndrome.Methods:According to the 2008 guidelines for diagnosis and treatment of common diseases in internal medicine of traditional Chinese medicine(diseases of Western Medicine),clinical diagnosis and treatment terms of traditional Chinese medicine(syndrome),guiding principles for clinical research of new drugs of traditional Chinese medicine(2002 Edition)and diagnostic and curative effect standards for diseases and syndromes of traditional Chinese medicine(2012 Edition),the data from July 2019 to December 2020 were included,A total of 32 patients with stable angina pectoris of phlegm and blood stasis type were diagnosed in the Department of Cardiology,Dongzhimen Hospital,Beijing University of traditional Chinese medicine.The control group was given conventional secondary prevention drugs for coronary heart disease,while the treatment group was given Danlou tablets on the basis of conventional secondary prevention drugs:morning,middle and half an hour after dinner,oral 3 times a day,5 tablets each time,for 24 weeks.The angina score and nitroglycerin stopping rate were observed before and after treatment.The course of treatment was 24 weeks.Results:The difference of angina score between the treatment group and the control group was statistically significant(p<0.05);The stopping rate of nitroglycerin in the treatment group was higher than that in the control group.Conclusion:Danlou tablets combined with conventional secondary prevention drugs for coronary heart disease can reduce angina pectoris score,improve nitroglycerin stopping rate,and have good safety,and the effect is better than that of simple secondary prevention treatment for coronary heart disease. |
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