The Experimental Reaseach Of Xiaoke No.1 Decoction Effect On Sugarand Fat Metabolish For Diabetic Rats

Objective:Through the animal experiment research on the prescription of treating diabetes,the prescription of Xiaoke NO.1 Decoction,observe the effect of the filter,and explore its mechanism.Methods:By high fat feed and STZ combination induce the diabetic rat model.Building a successful rats were randomly divided into model control group,Xiaoke NO.1 Decoctionlow dose group,Xiaokel middle dose group,Xiaoke NO.1 Decoctionhigh dose group,Yunvjian group.Observed the rats in the experiment diet,drinking water,body weight,blood glucose detection in blood of rats.The fasting blood glucose,8 weeks after the administration of TG,TC,HDL-C,LDL-C,glucagon levels.Collect rat kidney,pancreas,observe the change of rat’s organ histopathology.Result:Experiments show that Xiaoke NO.1 Decoctioncan reduce diabetes diet quantity and water quantity,reduce the body weight of rats.4 weeks to 8 weeks after the treatment,the rats of Xiaoke NO.1 Decoction groups blood glucose were lower than that of model control group.C peptide levels of Xiaoke NO.1 Decoction group higher than the control group of rats.The rats of Xiaoke NO.1 Decoction insulin levels were higher than the control group.The rats of Xiaoke NO.1 Decoction glucagon levels are lower than the model control group.Each group rats of Xiaoke NO.1 Decoction TG content is lower than the model control group.Each group rats of Xiaoke NO.1 Decoction TC content is lower than the model control group.Each group rats of Xiaoke NO.1 Decoction LDL-C content is lower than the model control group.Each group rats of Xiaoke NO.1 Decoction HDL-C content is higher than the model control group.Observed under a microscope:Compared with the model group,Each group of Xiaoke NO.1 Decoction kidney exudate,edema and less sediment pink degree is low;the number of pancreatic islet cells,nuclear and nuclear condensation were reduced,edema and degeneration the relatively mild degree of change that Xiaoke No.1 dose group can improve effective,obvious effect on the recovery of function and slow the progression of the disease.Conclusion:Xiaoke NO.1 Decoction can reduce diabetic rats fasting blood glucose,glucagon levels,elevated insulin,C peptide levels.Xiaoke NO.1 Decoction can reduce diabetic rats TC,TG,LDL-C level,increase HDL-C level.Xiaoke NO.1 Decoction can reduce pathological damage of kidney and pancreas of the rats.